INT160633

Context Info Confidence 0.77 First Reported 2008 Last Reported 2010 Negated 2 Speculated 2 Reported most in Body Documents 21 Total Number 24 Disease Relevance 10.01 Pain Relevance 2.73

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)

Anatomy Link Frequency parathyroid 5 macrophages 2 dendritic cells 2 muscle cell 2 monocytes 2 Vdr (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 108 94.64 antiepileptic Drug 2 83.44 carbamazepine 2 78.64 member 8 7 75.00 Central nervous system 198 72.96 Bile 78 67.20 cINOD 8 54.28 Inflammation 85 54.12 dexamethasone 33 50.00 COX2 2 48.40

Disease Link Frequency Relevance Heat Targeted Disruption 73 99.78 Stress Fractures 106 98.88 Rickets 40 95.76 Hyperplasia 8 95.24 Multiple Sclerosis 450 94.64 Polyps 9 88.88 Recurrence 9 87.32 Colon Cancer 30 86.72 Congenital Anomalies 3 86.08 Cancer 86 83.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Vitamin D receptor (VDR) transcription and protein levels were measured to examine whether VDR expression mediates differential regulation of duodenal TRPV6 between WT and KO mice, but expression and levels of VDR were similar in both genotypes.

Gene_expression (expression) of VDR associated with targeted disruption

1) Confidence 0.77 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19777446 Disease Relevance 0.60 Pain Relevance 0.07

Vitamin D receptor (VDR) transcription and protein levels were measured to examine whether VDR expression mediates differential regulation of duodenal TRPV6 between WT and KO mice, but expression and levels of VDR were similar in both genotypes.

Spec (whether) Gene_expression (expression) of VDR associated with targeted disruption

2) Confidence 0.77 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19777446 Disease Relevance 0.72 Pain Relevance 0.07

Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.

Gene_expression (expressions) of VDR in parathyroid

3) Confidence 0.69 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0

Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.

Gene_expression (expressions) of vitamin D receptor in parathyroid

4) Confidence 0.69 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0

The vitamin D receptor (VDR) is present in muscle cells, and the number of VDRs on each muscle cell appears to decrease with age [8].

Gene_expression (present) of VDR in muscle cell

5) Confidence 0.67 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.07 Pain Relevance 0

The vitamin D receptor (VDR) is present in muscle cells, and the number of VDRs on each muscle cell appears to decrease with age [8].

Gene_expression (present) of vitamin D receptor in muscle cell

6) Confidence 0.67 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.07 Pain Relevance 0

The VDR-null mouse (lacking the VDR) has a phenotype characterized by reduced bone size, body size, weight, motor coordination, and poor physical performance compared with wild-type mice [11].

Neg (lacking) Gene_expression (lacking) of VDR in body

7) Confidence 0.67 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.49 Pain Relevance 0

The observed interaction between a CTR minor allele and the VDR C-A haplotype and their association with stress fractures may be explained by the inhibitory effect of these proteins on parathyroid hormone production.

Gene_expression (haplotype) of VDR in parathyroid associated with stress fractures

8) Confidence 0.67 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.35 Pain Relevance 0

Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes

Gene_expression (genes) of VDR

9) Confidence 0.67 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.26 Pain Relevance 0

mediated Foxp3 was inhibited by 1,25(OH)2D3 via the VDR signal on CD4+ T cells (Figure 4).

Gene_expression (signal) of VDR in T cells

10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.17 Pain Relevance 0.03

Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.

Gene_expression (expressions) of VDR in parathyroid

11) Confidence 0.54 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0

Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.

Gene_expression (expressions) of VDR in parathyroid

12) Confidence 0.54 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0

However, the direct effect of 1,25(OH)2D3 on the function and differentiation of T cells is largely unknown because VDR is not expressed in naïve T cells [30].

Neg (not) Gene_expression (expressed) of VDR in T cells

13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.23 Pain Relevance 0.09

Vitamin D is a well-known nutrient that acts as a modulator of calcium homeostasis and the immune response [17], and the vitamin D receptor (VDR) is expressed in several types of immune cells, including monocytes, macrophages, dendritic cells (DCs), and effector/memory T cells [18]–[20].

Gene_expression (expressed) of VDR in dendritic cells

14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.81 Pain Relevance 0.33

Thus, these inhibitory effects of 1,25(OH)2D3 are most pronounced in the effector/memory T cells which do express VDR or are mediated by 1,25(OH)2D3-treated DCs.

Gene_expression (express) of VDR in memory T cells

15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.18 Pain Relevance 0.06

Vitamin D is a well-known nutrient that acts as a modulator of calcium homeostasis and the immune response [17], and the vitamin D receptor (VDR) is expressed in several types of immune cells, including monocytes, macrophages, dendritic cells (DCs), and effector/memory T cells [18]–[20].

Gene_expression (expressed) of vitamin D receptor in dendritic cells

16) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.82 Pain Relevance 0.33

Although there is also a relatively high level of VDR expression in the small intestine, constitutive CYP24 expression in this tissue is very low or undetectable, in contrast to that in the kidney [Xu et al., 2006].

Gene_expression (expression) of VDR in kidney

17) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.26 Pain Relevance 0.21

Pascussi et al. first suggested that activation of SXR can enhance the expression of the VDR target gene, CYP24, which would increase the catabolism of 1,25(OH)2D3; thereby, leading to drug-induced osteomalacia [Pascussi et al., 2005].

Gene_expression (expression) of VDR associated with rickets

18) Confidence 0.45 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.08

Here, we explored the mechanism of dietary protection by hCa by analyzing the expression of genes involved in the regulation of Ca uptake/flux in the intestinal epithelium, including the Ca-sensing receptor, vitamin D receptor, Ca binding protein, and transient receptor potential cation channels, subfamily V, members 5 and 6 (TRPV5/6).

Spec (analyzing) Gene_expression (expression) of vitamin D receptor in intestinal epithelium

19) Confidence 0.19 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20508153 Disease Relevance 0.51 Pain Relevance 0.07

Vitamin D is a well-known nutrient that acts as a modulator of calcium homeostasis and the immune response [17], and the vitamin D receptor (VDR) is expressed in several types of immune cells, including monocytes, macrophages, dendritic cells (DCs), and effector/memory T cells [18]–[20].

Gene_expression (expressed) of VDR in macrophages

20) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.81 Pain Relevance 0.33

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