INT16089

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 17
Disease Relevance 3.37
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
Lung 4
liver 2
BMMC 2
macrophages 1
Ltc4s (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.20 Very High Very High Very High
diclofenac 5 98.50 Very High Very High Very High
Inflammation 137 96.80 Very High Very High Very High
Arthritis 1 94.24 High High
cytokine 98 89.60 High High
Analgesic 1 89.52 High High
cINOD 6 83.84 Quite High
chemokine 35 80.16 Quite High
Pain 5 75.00 Quite High
fibrosis 56 41.92 Quite Low
Disease Link Frequency Relevance Heat
Hypertrophy 7 99.60 Very High Very High Very High
Airway Remodeling 182 98.00 Very High Very High Very High
Asthma 98 97.72 Very High Very High Very High
INFLAMMATION 148 96.80 Very High Very High Very High
Experimental Arthritis 1 94.96 High High
Pressure And Volume Under Development 1 91.12 High High
Hepatitis 2 82.16 Quite High
Pain 2 75.00 Quite High
Hepatotoxicity 2 75.00 Quite High
Fibrosis 63 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All five metabolites were more than 50 times less potent than diclofenac in inhibiting PGE2 production in zymosan-stimulated mouse macrophages and LTC4 synthesis was not inhibited in these cells.
Gene_expression (synthesis) of LTC4 in macrophages associated with diclofenac
1) Confidence 0.77 Published 1991 Journal Agents Actions Section Abstract Doc Link 1793018 Disease Relevance 0.28 Pain Relevance 0.39
Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4).
Gene_expression (synthesis) of leukotriene C4 in liver associated with paracetamol
2) Confidence 0.60 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.16 Pain Relevance 0.42
Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4).
Gene_expression (synthesis) of LTC4 in liver associated with paracetamol
3) Confidence 0.60 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.16 Pain Relevance 0.42
In vitro studies demonstrated that zymosan stimulates LTC4 synthesis by peritoneal cells whereas LTE4, LTD4, LTB4 or monoHETES were not detectable (using HPLC methods).
Gene_expression (synthesis) of LTC4
4) Confidence 0.51 Published 1985 Journal Prostaglandins Section Abstract Doc Link 3001831 Disease Relevance 0.22 Pain Relevance 0.18
Furthermore, this compound consistently inhibited the production of leukotriene C4 (LTC4), as well as the degranulation reaction in BMMC, with an IC50 value of 5.7 microM and 9 microM, respectively, and these effects occurred in a dose dependent fashion.
Gene_expression (production) of LTC4 in BMMC
5) Confidence 0.46 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365692 Disease Relevance 0 Pain Relevance 0.07
Furthermore, this compound consistently inhibited the production of leukotriene C4 (LTC4), as well as the degranulation reaction in BMMC, with an IC50 value of 5.7 microM and 9 microM, respectively, and these effects occurred in a dose dependent fashion.
Gene_expression (production) of leukotriene C4 in BMMC
6) Confidence 0.46 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365692 Disease Relevance 0 Pain Relevance 0.07
In addition, this compound consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 6.56 microM.
Gene_expression (production) of LTC4
7) Confidence 0.44 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 16681032 Disease Relevance 0 Pain Relevance 0.07
In addition, this compound consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 6.56 microM.
Gene_expression (production) of leukotriene C4
8) Confidence 0.44 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 16681032 Disease Relevance 0 Pain Relevance 0.07
As LTC4 is expressed by eosinophils [19] and has pro-remodeling potential in asthma [20], we examined whether Siglec-F deficient mice had increased levels of lung LTC4 in their remodeled airways.
Gene_expression (expressed) of LTC4 in lung associated with asthma
9) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.77 Pain Relevance 0
Our initial experiments to address this question demonstrate no differences in levels of IL-13 or LTC4 between Siglec-F deficient and WT mice.
Gene_expression (levels) of LTC4
10) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.32 Pain Relevance 0.04
Levels of lung LTC4 in chronic OVA challenged Siglec-F deficient mice were significantly higher than in non-OVA challenged Siglec-F deficient mice (p < 0.02), but these levels were not significantly different from that noted in chronic OVA challenged WT mice (Figure 3D).


Gene_expression (Levels) of LTC4 in lung
11) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0
Lung LTC4 levels
Gene_expression (Lung) of LTC4 in Lung
12) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.09 Pain Relevance 0.16
As there was no significant difference in levels of LTC4 in the remodeled airways of WT and Siglec-F deficient mice, LTC4 is unlikely to explain the differences in levels of airway remodeling in WT and Siglec-F deficient mice.
Gene_expression (is) of LTC4 associated with airway remodeling
13) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.60 Pain Relevance 0.03
Lung LTC4 levels
Gene_expression (levels) of LTC4 in Lung
14) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.09 Pain Relevance 0.16
As there was no significant difference in levels of LTC4 in the remodeled airways of WT and Siglec-F deficient mice, LTC4 is unlikely to explain the differences in levels of airway remodeling in WT and Siglec-F deficient mice.
Gene_expression (levels) of LTC4 associated with airway remodeling
15) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.68 Pain Relevance 0.03
Furthermore, MG consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 5.3 microM.
Gene_expression (production) of LTC4
16) Confidence 0.15 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 17121182 Disease Relevance 0 Pain Relevance 0.08
Furthermore, MG consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 5.3 microM.
Gene_expression (production) of leukotriene C4
17) Confidence 0.15 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 17121182 Disease Relevance 0 Pain Relevance 0.08

General Comments

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