INT160993

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
CPu 1
Cpb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 41 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Dopamine 11 99.12 Very High Very High Very High
monoamine 4 98.98 Very High Very High Very High
anesthesia 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 120 96.44 Very High Very High Very High
Loss Of Sense Of Smell 1 89.20 High High
Toxicity 2 84.24 Quite High
Disease 36 75.00 Quite High
Gliosis 1 74.08 Quite High
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Inborn Genetic Diseases 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, starting after three MPTPp injections, we observed a gradual decline of TH-positive cells in the SNc, and a gradual raise of enkephalin mRNA in the CPu.
Negative_regulation (raise) of CPu in CPu associated with enkephalin
1) Confidence 0.18 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.46 Pain Relevance 0.39
In addition, a significant increase in GFAP staining corresponded well with the loss of TH in both the SN and CPu.
Negative_regulation (loss) of CPu associated with substantia nigra
2) Confidence 0.14 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3005838 Disease Relevance 0.63 Pain Relevance 0.22
As was expected, the amount of both monoamine transporter proteins, in non-NDI1 samples, in the CPu was decreased when compared to controls as well as the levels of TH after 2 weeks.
Negative_regulation (decreased) of CPu associated with monoamine
3) Confidence 0.14 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3005838 Disease Relevance 0.60 Pain Relevance 0.22

General Comments

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