INT161000

Context Info Confidence 0.05 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.37

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe) structural molecule activity (Gfap) Golgi apparatus (Cpe) extracellular matrix organization (Gfap)

Anatomy Link Frequency caudate-putamen 1 Cpe (Mus musculus) Gfap (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 5 100.00 Enkephalin 4 100.00 Substantia nigra 1 97.88

Disease Link Frequency Relevance Heat Loss Of Sense Of Smell 1 92.16 Parkinson's Disease 2 86.08 Disease 6 85.84 Gliosis 1 40.16 Pathologic Processes 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We evaluated behavioral deficits (olfactory and motor impairment), neurodegeneration (loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra pars compacta, SNc), biochemical markers of functional impairment in the caudate-putamen (CPu) (striatal enkephalin mRNA, DA and DOPAC levels), and glial reactivity (CD11b and GFAP immunoreactivity in the SNc and CPu) at progressive time-points (after 1, 3, 7, and 10 administrations of MPTPp).

enkephalin mRNA Binding (immunoreactivity) of GFAP in caudate-putamen associated with dopamine, substantia nigra and enkephalin

1) Confidence 0.05 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.53 Pain Relevance 0.37

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