INT161308

Context Info Confidence 0.12 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.86

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) small molecule metabolic process (POMC) DNA binding (JUN) cell-cell signaling (POMC)

Anatomy Link Frequency T lymphocytes 2 POMC (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Endogenous opioid 1 99.98 Morphine 3 99.46 Opioid 6 94.08 Pain 1 83.12 mu opioid receptor 1 38.24

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 1 92.40 Cancer 1 92.08 Pain 1 83.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We demonstrated that morphine and the endogenous opioid beta-endorphin inhibited the transcription of IL-2 in activated human T lymphocytes as well as the activation of the transcription factors AP-1, NFAT, and NF-kappaB, which transactivate IL-2.

beta-endorphin Negative_regulation (inhibited) of Positive_regulation (activation) of AP-1 in T lymphocytes associated with endogenous opioid and morphine

1) Confidence 0.12 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19561113 Disease Relevance 0.27 Pain Relevance 0.86

General Comments

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