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Context Info
Confidence 0.23
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C6)
Anatomy Link Frequency
articular 1
cardiomyocytes 1
C6 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 4 99.74 Very High Very High Very High
Spinal cord 2 88.40 High High
Pain 1 87.84 High High
Physical dependence 2 87.12 High High
Morphine 1 82.72 Quite High
analgesia 1 82.00 Quite High
Snapping jaw 1 75.00 Quite High
withdrawal 1 73.92 Quite High
narcan 1 66.16 Quite High
substantia gelatinosa 2 65.04 Quite High
Disease Link Frequency Relevance Heat
Aging 1 94.84 High High
Pain 1 87.84 High High
Drug Dependence 2 87.12 High High
Temporomandibular Joint Syndrome 1 75.00 Quite High
Natriuresis 5 50.00 Quite Low
Hypertension 3 17.64 Low Low
Coronary Heart Disease 13 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in neonatal rat cardiomyocytes have indicated that Ang II induces TRPC3/C6 activation through G?
Positive_regulation (activation) of C6 in cardiomyocytes
1) Confidence 0.23 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
The analgesic activity of C-6-S and D-6-S was equipotent to that of CPN and DMN by the acetic acid writhing test on the s.c. injection, and the activity of N-6-S was about 2 times more potent than that of nalorphine.
Positive_regulation (equipotent) of C-6-S associated with analgesic
2) Confidence 0.13 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1797421 Disease Relevance 0.09 Pain Relevance 0.49
Three Hox genes (a4, b2, and b8) were activated and ten Hox genes (c6, c8, c9, c10, c13, d1, d8, d9, and d10) were repressed by Lbx1.
Positive_regulation (activated) of c6
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0.09 Pain Relevance 0.16
From these observations it appears that the articular disc shows more of the characteristics of cartilage, as evidenced by the increased amounts of C6S and KS/C4S during the mandibular growth spurt at the ages of 6 and 7 weeks, similar to that of type III collagen.
Positive_regulation (increased) of C6S in articular
4) Confidence 0.00 Published 1993 Journal Arch. Oral Biol. Section Abstract Doc Link 8343068 Disease Relevance 0.17 Pain Relevance 0.07

General Comments

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