INT16159

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Context Info
Confidence 0.38
First Reported 1984
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 2.52
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
nerve 2
mesenteric vein 1
blood 1
muscle 1
vena cava 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 100.00 Very High Very High Very High
noradrenaline 6 99.68 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 4 99.38 Very High Very High Very High
ischemia 7 98.98 Very High Very High Very High
Inflammation 19 98.72 Very High Very High Very High
bradykinin 7 98.52 Very High Very High Very High
agonist 13 97.28 Very High Very High Very High
antagonist 12 96.24 Very High Very High Very High
Clonidine 2 94.12 High High
diclofenac 4 93.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Cv Unclassified Under Development 2 98.98 Very High Very High Very High
Body Weight 1 94.96 High High
Peritonitis 2 89.08 High High
Stress 2 87.76 High High
Heart Rate Under Development 1 85.44 High High
Coronary Artery Disease 5 84.68 Quite High
Anaphylaxis 1 82.96 Quite High
Coagulation Disorder 5 80.16 Quite High
Pleurisy 2 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of LTC4 and PGI2 on all parameters were similar at doses below 3 micrograms/kg bw.
Regulation (effects) of LTC4
1) Confidence 0.38 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3133096 Disease Relevance 0.26 Pain Relevance 0.09
The R(-) enantiomer had no effect on LTC4 release from any of the tissues investigated.
Neg (no) Regulation (effect) of LTC4
2) Confidence 0.29 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1801061 Disease Relevance 0.20 Pain Relevance 0.03
While SA had no effect on LTC4, ASA blocked the effects of LTC4 upon both tracheal pressure and nerve activity.
Neg (no) Regulation (effect) of LTC4 in nerve
3) Confidence 0.14 Published 1984 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6597448 Disease Relevance 0.16 Pain Relevance 0.34
The TXB2/6KPGF1 alpha ratio in coronary sinus blood significantly increased after ischemia in both EX and PTCA, but there was no significant change in LTC4 levels of coronary sinus blood immediately after acute ischemia.
Neg (no) Regulation (change) of LTC4 in blood associated with ischemia and percutaneous transluminal coronary angioplasty
4) Confidence 0.11 Published 1990 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2329180 Disease Relevance 0.81 Pain Relevance 0.60
The effects of the sulfidopeptide leukotrienes (LT), LTC4, LTD4 and LTE4 on short-circuit current (Isc), a measure of active ion transport, were determined in muscle-stripped mucosa sheets from the guinea pig distal colon.
Regulation (effects) of LTC4 in muscle
5) Confidence 0.09 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093730 Disease Relevance 0 Pain Relevance 0.04
While SA had no effect on LTC4, ASA blocked the effects of LTC4 upon both tracheal pressure and nerve activity.
Regulation (effects) of LTC4 in nerve
6) Confidence 0.09 Published 1984 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6597448 Disease Relevance 0.16 Pain Relevance 0.33
We therefore investigated the effects of the inflammatory mediators, prostaglandin (PGD2, PGE2, PGI2, and PGF2 alpha) and leukotriene (LTC4), on guinea-pig colonic secretion and on electrophysiological behaviour of submucosal neurones.
Spec (investigated) Regulation (effects) of LTC4 associated with inflammatory mediators
7) Confidence 0.05 Published 1997 Journal Comp. Biochem. Physiol. A Physiol. Section Abstract Doc Link 9366066 Disease Relevance 0.42 Pain Relevance 0.42
Doses of meloxicam sufficient to inhibit PGE2 biosynthesis in the pleural exudate and peritoneal exudate had no influence on leukotriene-B4 (LTB4) or leukotriene-C4 (LTC4) content.
Neg (no) Regulation (influence) of LTC4 in PGE2
8) Confidence 0.04 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.44 Pain Relevance 0.39
LTC4 and LTD4 concentration-response curves were not significantly affected when conducted in the presence of any of the following: 10(-7) M propranolol (beta-adrenoceptor antagonist), 10(-6) M chlorpheniramine (H1-receptor antagonist), 10(-6) M ketanserin (nonselective 5-hydroxytryptamine receptor antagonist), 10(-7) M atropine (muscarinic receptor antagonist), and 10(-6) M tetrodotoxin (sodium channel blocker).
Neg (not) Regulation (affected) of LTC4 associated with tetrodotoxin, antagonist and sodium channel
9) Confidence 0.04 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0.08 Pain Relevance 0.32
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Regulation (response) of LTC4 in mesenteric vein associated with noradrenaline
10) Confidence 0.03 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28
The effects of peptidoleukotriene C4 (LTC4) on electrical properties and Na+ and Cl- fluxes in the presence or absence of the LTD4/LTE4 antagonist, 2(S)-hydroxy-3-(R)-carboxyethylthio)-3-[2-(8-phenyloctyl)phe nyl] propanoic acid (SK&F 104353) were investigated in stripped ileal mucosa from rabbits placed in Ussing chambers.
Spec (investigated) Regulation (effects) of LTC4 associated with antagonist
11) Confidence 0.03 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2156177 Disease Relevance 0 Pain Relevance 0.05
The spectrum of the bound ligand was essentially identical to that of the free ligand, indicating that the protein binds but does not chemically modify LTC4 (Figure S3).


Neg (not) Regulation (modify) of LTC4
12) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.05
The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2 alpha, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries.
Regulation (response) of LTC4 in vena cava associated with noradrenaline
13) Confidence 0.01 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2761127 Disease Relevance 0 Pain Relevance 0.28

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