INT161609

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 2.16
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HSH2D) cytoplasm (HSH2D)
Anatomy Link Frequency
receptor cell 1
HSH2D (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 14 99.32 Very High Very High Very High
aspirin 18 99.00 Very High Very High Very High
Inflammatory response 9 84.88 Quite High
Inflammation 201 78.04 Quite High
cINOD 36 53.16 Quite High
rheumatoid arthritis 21 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
acular 7 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 49 99.20 Very High Very High Very High
Blister 2 88.52 High High
Pressure And Volume Under Development 1 85.80 High High
INFLAMMATION 231 84.52 Quite High
Peritonitis 1 74.96 Quite High
Increased Venous Pressure Under Development 1 72.60 Quite High
Alzheimer's Dementia 7 60.56 Quite High
Disease 15 57.12 Quite High
Apoptosis 35 5.00 Very Low Very Low Very Low
Cancer 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, aspirin(low) triggered 15-epi-lipoxin A(4) synthesis and up-regulated its receptor (FPRL1, ALX).
Positive_regulation (up-regulated) of ALX associated with aspirin
1) Confidence 0.45 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597002 Disease Relevance 0.81 Pain Relevance 0.58
Finally, AnxA1 activation of ALX on the human PMN inhibited interaction with HUVEC monolayers as assessed with the flow chamber system.
Positive_regulation (activation) of ALX
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.20 Pain Relevance 0.07
HEK293 cells transfected with ALX receptor were treated with 0.5 µM AnxA1 or with 10 µM Ac2-26 for 4 hours; these concentrations were validated to produce rapid signalling responses (e.g. phospho-ERK) via ALX activation [16].
Positive_regulation (activation) of ALX
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.06 Pain Relevance 0.04
In order to obtain a global picture of gene expression changes associated with the activation of ALX receptor by the specific agonists AnxA1 and peptide Ac2-26, a whole-genome microarray study was carried out using GeneChip® Human Genome U133 Plus 2.0 (Affymetrix, Santa Clara, CA).
Positive_regulation (activation) of ALX receptor associated with agonist
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.19 Pain Relevance 0.05
There was a significant increase in positive fluorescent signal, in the ALX receptor transfected cells compared to CMV cells.
Positive_regulation (increase) of ALX receptor associated with cytomegalovirus infection
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.28 Pain Relevance 0
There is positive regulation upon AnxA1 (or peptide Ac2-26) addition, conveyed by ALX activation, and there is also negative regulation in tonic absence of this protein, as observed in AnxA1null mice.


Positive_regulation (activation) of ALX
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.06 Pain Relevance 0
These results suggest that the ALX transfected HEK293 cells have both i) detectable cell surface expression in the ALX protein and ii) that this expression is specific to the cloning procedure, as CMV empty vector transfected cells show no immunoreactivity for the anti-ALX antibody.
Neg (no) Positive_regulation (immunoreactivity) of anti-ALX associated with cytomegalovirus infection
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.32 Pain Relevance 0.03
Expression of ALX receptor cell surface protein was demonstrated in unstimulated ALX stably transfected HEK293 cells compared to empty vector controls (CMV) using flow cytometry analysis (Figure 1C).
Positive_regulation (unstimulated) of ALX in receptor cell associated with cytomegalovirus infection
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.24 Pain Relevance 0

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