INT161794

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.97
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
macrophages 2
Cd68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.58 Very High Very High Very High
tolerance 16 98.34 Very High Very High Very High
Inflammation 86 96.92 Very High Very High Very High
Arthritis 33 94.72 High High
psoriasis 23 94.40 High High
Nicotine 1 94.16 High High
Infliximab 32 91.80 High High
cva 1 90.16 High High
Inflammatory mediators 2 87.36 High High
rheumatoid arthritis 7 87.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 99.40 Very High Very High Very High
Pulmonary Disease 111 98.70 Very High Very High Very High
Seronegative Spondarthritis 28 94.72 High High
Psoriasis 39 94.40 High High
Pressure And Volume Under Development 2 90.56 High High
Nicotine Addiction 16 90.28 High High
Hemorrhage 1 90.16 High High
Rheumatoid Arthritis 7 87.08 High High
Lymphatic System Cancer 1 85.24 High High
Myeloid Sarcoma 1 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of central tolerance with intrathymic HUVEC-injection and the immunomodulatory strategy using pristane attenuated the expression of caspase-3 as well as the expression of CD68 and CD19.


Negative_regulation (attenuated) of Gene_expression (expression) of CD68 associated with tolerance
1) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.14 Pain Relevance 0.08
Immunohistochemical studies, performed in 7 cases showed a mixture of CD68+ histiocytes and CD3+ T cells, with few B cells (CD20+) and few granulocytes.
Negative_regulation (mixture) of Gene_expression (histiocytes) of CD68 in T cells
2) Confidence 0.21 Published 2009 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 19623033 Disease Relevance 1.27 Pain Relevance 0.21
In COPD, there is an abnormal inflammatory response, characterized by a predominance of CD8+ T-cells, CD68+ macrophages, and neutrophils in the conducting airways, lung parenchyma, and pulmonary vasculature (Soto and Hanania 2005; O’Donnell et al 2006; Wright and Churg 2006).
Negative_regulation (predominance) of Gene_expression (macrophages) of CD68 in T-cells associated with inflammatory response and pulmonary disease
3) Confidence 0.14 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.41 Pain Relevance 0.48
Although the reductions in CD3+ T cells and CD68+ macrophages in synovial tissue did not reach statistical significance, this might be accounted for by the relatively small number of patients from whom synovial biopsies could be obtained (n = 9).
Negative_regulation (reductions) of Gene_expression (macrophages) of CD68 in macrophages
4) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 1.14 Pain Relevance 0.82

General Comments

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