INT161805

Context Info Confidence 0.12 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.13

endosome (ECE1) peptidase activity (ECE1) plasma membrane (ECE1)

ECE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 3 98.48 Angina 1 39.52

Disease Link Frequency Relevance Heat Injury 2 99.20 Increased Venous Pressure Under Development 3 98.16 Coronary Vasospasm 3 85.40 Variant Angina Pectoris 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.

Positive_regulation (upregulated) of endothelin-converting enzyme associated with serotonin

1) Confidence 0.12 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.61 Pain Relevance 0.13

General Comments

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