INT161839

Context Info Confidence 0.47 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.47 Pain Relevance 0.14

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)

Anatomy Link Frequency condyles 2 Tnfrsf11b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Snapping jaw 2 75.00 anesthesia 1 5.00 complementary and alternative medicine 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 24 97.32 Stress 1 80.52 Temporomandibular Joint Syndrome 2 75.00 Hypercalcemia 4 30.00 Postmenopausal Osteoporosis 2 10.64 Body Weight 3 5.00 Bone Cancer 3 5.00 Endometriosis (extended) 3 5.00 Gonadal Disease 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, bone mineral density (BMD) and osteoprotegerin expression in extracted-side condyles were significantly increased while osteoclast numbers were significantly decreased when compared with intact-side condyles.

Positive_regulation (increased) of Gene_expression (expression) of osteoprotegerin in condyles

1) Confidence 0.47 Published 2009 Journal Eur. J. Oral Sci. Section Abstract Doc Link 19627347 Disease Relevance 0.16 Pain Relevance 0.14

As shown in Fig. 5A, HEP extract significantly increased OPG mRNA expression in UMR 106 cells in a dose-dependent manner (P < 0.01).

Positive_regulation (increased) of Gene_expression (expression) of OPG mRNA

2) Confidence 0.31 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.31 Pain Relevance 0

General Comments

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