INT16189

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Context Info
Confidence 0.24
First Reported 1991
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.82
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Pls1) cellular_component (Pls1) biological_process (Pls1)
cytoplasm (Pls1)
Anatomy Link Frequency
plasma 1
brain 1
Phr 1
upper 1
posterior pituitary 1
Pls1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 19 100.00 Very High Very High Very High
antinociception 4 99.84 Very High Very High Very High
intrathecal 8 99.62 Very High Very High Very High
isoflurane 6 98.56 Very High Very High Very High
Morphine 6 95.00 High High
Neuropeptide 2 93.32 High High
conotoxin 2 89.76 High High
Antinociceptive 6 89.36 High High
Analgesic 6 88.00 High High
ketamine 6 85.60 High High
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 3 100.00 Very High Very High Very High
Nociception 2 98.12 Very High Very High Very High
Diabetes Mellitus 11 97.64 Very High Very High Very High
Hypoxia 7 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phr and Xs1 I activities were little affected, and changes in inspiratory time were small.
Neg (little) Regulation (affected) of Xs1 I in Phr
1) Confidence 0.24 Published 1991 Journal Jpn. J. Physiol. Section Abstract Doc Link 1806672 Disease Relevance 0.48 Pain Relevance 0
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Regulation (effect) of OTNP-I in posterior pituitary associated with stress
2) Confidence 0.05 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
When the test pulse was preceded by a depolarizing prepulse, the prepulse positive to -50 mV preferentially inactivated TTX-S with a minimal effect on TTX-I.
Regulation (effect) of TTX-I associated with tetrodotoxin
3) Confidence 0.05 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 9026782 Disease Relevance 0 Pain Relevance 1.58
Therefore, the present results show that, like omega-CTX-MVIIA, the intrathecal administration of HWTX-I is effective in antinociception in the rat model of the formalin test.
Regulation (effective) of HWTX-I associated with antinociception and intrathecal
4) Confidence 0.04 Published 2005 Journal Toxicon Section Abstract Doc Link 15581678 Disease Relevance 0.06 Pain Relevance 0.72
In addition, we examined the effect of insulin treatment, begun 2 weeks after induction of diabetes and continued for 3 more weeks, on isoflurane MED and on brain synaptic PMCA and phospholipid-N-methyltransferase I (PLMT I), another enzyme altered by inhalation anesthetics (IA).
Regulation (altered) of PLMT I in brain associated with diabetes mellitus and isoflurane
5) Confidence 0.04 Published 1995 Journal Life Sci. Section Abstract Doc Link 7752806 Disease Relevance 0.76 Pain Relevance 0.24
In addition plasma concentrations of OTNP-I and OTNP-II were above the baseline.
Regulation (concentrations) of OTNP-I in plasma
6) Confidence 0.03 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.06 Pain Relevance 0.24
The ED50 values of HWTX-I and omega-CTX-MVIIA were 0.28 and 0.19 microg/kg, respectively.
Regulation (values) of HWTX-I
7) Confidence 0.03 Published 2005 Journal Toxicon Section Abstract Doc Link 15581678 Disease Relevance 0.10 Pain Relevance 0.65
Gastric motility was measured manometrically in response to injections of either recombinant purified apo A-IV (200 microg) or apo A-I, the structurally similar intestinal apolipoprotein not regulated by triglyceride absorption, close to the upper gastrointestinal tract in urethane-anesthetized rats.
Neg (not) Regulation (regulated) of A-I in upper associated with disorder of lipid metabolism
8) Confidence 0.01 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15117731 Disease Relevance 0.25 Pain Relevance 0.10

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