INT161973

Context Info Confidence 0.47 First Reported 2009 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.62 Pain Relevance 0.51

endoplasmic reticulum (UGT2B17)

UGT2B17 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 14 93.44 diclofenac 5 84.56 Bioavailability 2 55.44 Pain 2 5.00

Disease Link Frequency Relevance Heat Renal Disease 36 98.84 INFLAMMATION 4 93.04 Obesity 22 59.04 Injury 16 39.20 Focal Segmental Glomerulosclerosis 10 5.00 Chronic Renal Failure 8 5.00 Pulmonary Disease 8 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 6 5.00 Renal Failure 4 5.00 Keloid Scars 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The T/E might be affected by drugs that interact with UGT2B17, or other enzymes that contribute to testosterone glucuronidation.

UGT2B17 Spec (might) Binding (interact) of

1) Confidence 0.47 Published 2009 Journal Steroids Section Abstract Doc Link 19643121 Disease Relevance 0.17 Pain Relevance 0.49

This report postulates the association of deletion polymorphism in the UGT2B17 gene with the occurrence of renal disorders on chronic exposure to AAS.

UGT2B17 Binding (association) of associated with renal disease

2) Confidence 0.36 Published 2010 Journal Subst Abuse Treat Prev Policy Section Abstract Doc Link PMC2877023 Disease Relevance 0.38 Pain Relevance 0

Sjöqvist et al. examined the association of androgen excretion with UGT2B17 deletion in a population based study comprising of Korean and Swedish participants [22].

UGT2B17 Spec (examined) Binding (association) of

3) Confidence 0.31 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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