INT161974

Context Info Confidence 0.26 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.31 Pain Relevance 0.99

endoplasmic reticulum (UGT2B15)

UGT2B15 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 10 99.48 diclofenac 4 95.36 Pain 1 62.40 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 3 91.20 Pain 1 62.40 Renal Disease 18 50.00 Proteinuria 2 18.40 Focal Segmental Glomerulosclerosis 5 16.32 Injury 8 10.80 Keloid Scars 2 8.72 Obesity 11 5.00 Chronic Renal Failure 4 5.00 Pulmonary Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, UGT2B15 was more sensitive than UGT2B17 to the two drugs, particularly to ibuprofen.

Regulation (sensitive) of UGT2B15

1) Confidence 0.26 Published 2009 Journal Steroids Section Abstract Doc Link 19643121 Disease Relevance 0.15 Pain Relevance 0.51

Compared to UGT2B17, UGT2B15 was found to be more sensitive to both the NSAIDs, particularly ibuprofen.

Regulation (sensitive) of UGT2B15 associated with cinod

2) Confidence 0.22 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.15 Pain Relevance 0.47

General Comments

This test has worked.