INT162109

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
endometrium 4
MCF-7 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 1 85.76 High High
depression 2 78.00 Quite High
alcohol 2 75.92 Quite High
endometriosis 4 50.00 Quite Low
Pain 5 10.00 Low Low
imagery 8 6.40 Low Low
cva 7 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 17 99.84 Very High Very High Very High
Cancer 14 99.76 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 1 97.20 Very High Very High Very High
Ovarian Cysts 3 97.16 Very High Very High Very High
Breast Cancer 60 95.88 Very High Very High Very High
Ductal Carcinoma 1 95.36 Very High Very High Very High
Body Weight 1 91.56 High High
Poisoning 1 80.44 Quite High
Suicidal Behaviour 12 79.44 Quite High
Depression 2 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor was highly positive for estrogen receptor (ER) expression (95%), but less than 10% positive for progesterone receptor (PR) expression.
Negative_regulation (positive) of Gene_expression (expression) of estrogen receptor associated with cancer
1) Confidence 0.16 Published 2008 Journal Cases J Section Body Doc Link PMC2565669 Disease Relevance 1.52 Pain Relevance 0.08
Arzoxifene reduced estrogen receptor expression in endometrial cancer cell lines (ECC-1) (Dardes et al. 2001), an effect that was not reproducible in breast cancer cell lines (MCF-7) (Detre et al. 2003).
Negative_regulation (reduced) of Gene_expression (expression) of estrogen receptor in MCF-7 associated with endometriosis (extended) and breast cancer
2) Confidence 0.08 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.64 Pain Relevance 0.04
Expression of ER-alpha and PRA by the glandular epithelium was lower in the eutopic endometrium after both treatments, but this reduction was noted in the ectopic endometrium only after LNG-IUS treatments (P < 0.05).
Negative_regulation (lower) of Gene_expression (Expression) of ER-alpha in endometrium
3) Confidence 0.08 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.13 Pain Relevance 0
CONCLUSIONS: LNG-IUS reduced both cell proliferation and the expression of PRA and ER-alpha and increased Fas expression in the eutopic and ectopic endometrium of patients with endometriosis.
Negative_regulation (reduced) of Gene_expression (expression) of ER-alpha in endometrium
4) Confidence 0.08 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.11 Pain Relevance 0

General Comments

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