INT162428

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ar) nucleus (Ar) enzyme binding (Ar)
DNA binding (Ar) transcription factor binding (Ar) cytoplasm (Ar)
Ar (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 71.12 Quite High
antagonist 4 47.92 Quite Low
Calcium channel 2 39.96 Quite Low
Inflammation 5 30.48 Quite Low
Pain 1 12.60 Low Low
withdrawal 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 6 97.42 Very High Very High Very High
Motor Neuron Diseases 10 91.60 High High
Shock 1 90.80 High High
Disorders Of The Lacrimal System 85 87.84 High High
Metastasis 6 85.44 High High
Cancer 30 79.44 Quite High
Severe Combined Immunodeficiency 5 77.08 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 67.76 Quite High
Disease Progression 2 67.20 Quite High
Nerve Degeneration 1 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal studies have revealed that the pathogenesis of SBMA depends on the serum testosterone level and that androgen deprivation mitigates neurodegeneration through inhibition of nuclear accumulation of the pathogenic androgen receptor (AR).
Localization (accumulation) of androgen receptor associated with muscular atrophy
1) Confidence 0.37 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19697878 Disease Relevance 1.43 Pain Relevance 0.07
The pellets were purchased from Innovative Research of America (Sarasota, FL) and were designed for the constant release of placebo or physiological amounts of androgen (for a male [33-36]) for 3 weeks.
Localization (release) of androgen
2) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.27 Pain Relevance 0
Because an inhibition of SphK1 was observed during short-term androgen deprivation in vitro (Fig. 1D) and in vivo (Fig. 2B), we verified whether transfection of LNCaP cells with SphK1 might render these cells more resistant to androgen depletion.
Localization (depletion) of androgen
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.63 Pain Relevance 0
It has been recently suggested that nuclear export of androgen receptor is independent of CRT [60].
Localization (export) of androgen receptor
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0

General Comments

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