INT162464

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Latest revision as of 00:25, 22 September 2012

Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ERN1) endoplasmic reticulum (ERN1)
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.32 Very High Very High Very High
tolerance 1 97.92 Very High Very High Very High
aspirin 4 73.28 Quite High
cINOD 5 72.40 Quite High
Paresthesia 2 35.24 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.92 Very High Very High Very High
Death 5 98.20 Very High Very High Very High
Apoptosis 9 97.76 Very High Very High Very High
Cancer 1 90.56 High High
INFLAMMATION 3 70.96 Quite High
Increased Venous Pressure Under Development 53 68.88 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 50.00 Quite Low
Pruritus 2 35.60 Quite Low
Dysesthesia 2 35.24 Quite Low
Disorder Of Lipid Metabolism 23 5.00 Very Low Very Low Very Low

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Gene_expression (levels) of IRE1 associated with stress and qutenza
1) Confidence 0.36 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Also, the persistence of symptoms over a 24 weeks period in the ERN group suggested that most of the patients do not develop tolerance and explains the high discontinuation rates in the first year in clinical practice.38
Positive_regulation (period) of Gene_expression (group) of ERN associated with tolerance
2) Confidence 0.13 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.43 Pain Relevance 0.23

[edit] General Comments

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