INT162533

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.61
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Lgals3) nucleus (Lgals3) extracellular matrix organization (Lgals3)
cytoplasm (Lgals3)
Anatomy Link Frequency
heart 3
white matter 2
thyroid 1
microglia 1
Lgals3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 46 99.76 Very High Very High Very High
Inflammation 23 99.36 Very High Very High Very High
Antinociceptive 3 96.48 Very High Very High Very High
Nerve growth factor 144 94.48 High High
fibrosis 92 94.28 High High
anesthesia 8 91.76 High High
metalloproteinase 16 87.00 High High
Inflammatory response 4 79.96 Quite High
Sciatic nerve 6 63.20 Quite High
ischemia 6 62.44 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 44 99.60 Very High Very High Very High
INFLAMMATION 24 99.36 Very High Very High Very High
Natriuresis 12 99.36 Very High Very High Very High
Injury 139 98.88 Very High Very High Very High
Diffuse Axonal Injury 24 98.48 Very High Very High Very High
Toxicity 2 97.00 Very High Very High Very High
Fibrosis 80 94.28 High High
Coronary Heart Disease 4 94.24 High High
Cancer 108 92.24 High High
Brain Injury 141 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, by using in vivo and ex vivo experimental models of thyroid cancer we show the possibility to obtain a reliable thyroid cancer imaging in vivo by targeting the galectin-3 lectin molecule.
Regulation (targeting) of galectin-3 lectin in thyroid associated with thyroid neoplasm and imagery
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.94 Pain Relevance 0.10
Inflammatory signals also contribute in the regulation of galectin-3.
Regulation (regulation) of galectin-3 associated with inflammation
2) Confidence 0.37 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.49 Pain Relevance 0.12
Galectin-3 down-regulation in stable interfered ARO cells was checked in western blot at different time points (12–72 hrs).
Regulation (regulation) of Galectin-3
3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582451 Disease Relevance 0.52 Pain Relevance 0.03
In these studies, we explored whether there is up regulation of galectin-3/Mac-2 immunoreactive microglia within the corpus callosum following diffuse axonal injury and whether these microglia are a potential source of another trophic factor, nerve growth factor (NGF), in the injured subcortical white matter.
Spec (whether) Regulation (regulation) of Mac-2 immunoreactive microglia in white matter associated with nerve growth factor and diffuse axonal injury
4) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.69 Pain Relevance 0.30
In these studies, we explored whether there is up regulation of galectin-3/Mac-2 immunoreactive microglia within the corpus callosum following diffuse axonal injury and whether these microglia are a potential source of another trophic factor, nerve growth factor (NGF), in the injured subcortical white matter.
Spec (whether) Regulation (regulation) of galectin-3 in white matter associated with nerve growth factor and diffuse axonal injury
5) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.68 Pain Relevance 0.29
Interestingly, changes in galectin-3/Mac-2-ir microglia were also observed in sham animals.
Regulation (changes) of galectin-3/Mac-2-ir in microglia
6) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.77 Pain Relevance 0.12
Galectin-3 was the strongest regulated gene, being up-expressed in decompensated hearts more than fivefold compared with compensated hearts.
Regulation (regulated) of Galectin-3 in hearts
7) Confidence 0.22 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.59 Pain Relevance 0
In the heart, no direct evidence has been generated for inflammatory effects via galectin-3, although Sharma et al. [20] noted that, besides galectin-3, other genes encoding for immune factors were differentially regulated.
Regulation (regulated) of galectin-3 in heart associated with inflammation
8) Confidence 0.22 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 1.23 Pain Relevance 0.48
First, we do not know how galectin-3 is regulated at a transcriptional and translational level in the heart.
Regulation (regulated) of galectin-3 in heart
9) Confidence 0.22 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.50 Pain Relevance 0.12
The role of carbohydrate-binding sites was also investigated.
Regulation (role) of carbohydrate-binding
10) Confidence 0.07 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 19705102 Disease Relevance 0.19 Pain Relevance 0.17
As shown in Fig. 1, it consists of a cytotoxic A-chain with a molecular weight of 29 kDa and a carbohydrate-binding B-chain of 34 kDa that is responsible for its immunomodulatory efficacy.
Regulation (responsible) of carbohydrate-binding B-chain
11) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0 Pain Relevance 0

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