INT162757

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
neurons 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
gABA 17 99.98 Very High Very High Very High
Inflammatory response 5 95.72 Very High Very High Very High
Potency 16 95.32 Very High Very High Very High
Inflammation 40 92.40 High High
Arthritis 3 90.60 High High
Central nervous system 4 86.76 High High
Pain 7 85.56 High High
rheumatoid arthritis 29 84.96 Quite High
GABA receptor 2 79.92 Quite High
Disease Link Frequency Relevance Heat
Glioma 1 98.44 Very High Very High Very High
INFLAMMATION 48 95.36 Very High Very High Very High
Arthritis 9 90.60 High High
Pain 7 85.56 High High
Rheumatoid Arthritis 29 84.96 Quite High
Disease 11 70.24 Quite High
Ganglion Cysts 2 51.60 Quite High
Hyperalgesia 3 50.00 Quite Low
Demyelinating Disease 3 42.00 Quite Low
Myasthenia Gravis 3 41.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The localization of IL-1RI on sensory nerve fibres and its up-regulation in TG neurons during pulpal inflammation may imply a direct effect of IL-1 in pulpal nociception.
Regulation (regulation) of Localization (localization) of IL-1RI in neurons
1) Confidence 0.37 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.11 Pain Relevance 0
While the effects of GABA signaling on release of other proinflammatory cytokines such as IL-1 and TNF-?
Regulation (signaling) of Localization (release) of IL-1 associated with gaba and cytokine
2) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.12 Pain Relevance 1.12
expression vector did not change their response to IL-1?
Neg (not) Regulation (change) of Localization (response) of IL-1
3) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.13

General Comments

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