INT162782

Context Info Confidence 0.24 First Reported 2005 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 2 Total Number 6 Disease Relevance 2.09 Pain Relevance 0.18

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)

Tnfrsf11b (Rattus norvegicus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 4 96.88 Pain 1 94.24 Angina 4 5.00 anesthesia 1 5.00 complementary and alternative medicine 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 36 99.32 Bone Cancer 7 98.64 Cancer 4 97.48 Rheumatoid Arthritis 4 96.88 Pain 1 94.24 Disease 9 92.16 Hypercalcemia 26 88.92 Overweight 8 75.00 Apoptosis 2 66.84 Obesity 4 53.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that HEP extract might inhibit osteoclastogenesis via the modulation of the OPG/RANKL system in osteoblastic cells.

Spec (might) Regulation (modulation) of OPG associated with osteoporosis

1) Confidence 0.24 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.32 Pain Relevance 0

After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL.

Regulation (change) of serum OPG

2) Confidence 0.16 Published 2010 Journal Nutr J Section Abstract Doc Link PMC2818614 Disease Relevance 0.07 Pain Relevance 0

In the present study we found no significant associations for serum 25(OH)D with BMD, serum OPG or serum RANKL at baseline after adjustment for confounders, nor did vitamin D supplementation for one year differ form placebo regarding change in BMD, serum OPG or serum RANKL.

Regulation (change) of serum OPG

3) Confidence 0.16 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.08 Pain Relevance 0

No effect on OPG by bisphosphonate therapy has been reported in subjects with osteoporosis or rheumatoid arthritis [30,31], whereas a decrease in OPG after bisphosphonates has been found in subjects with Paget's disease [30].

Neg (No) Regulation (effect) of OPG associated with rheumatoid arthritis, osteoporosis and disease

4) Confidence 0.16 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.29 Pain Relevance 0.05

Thus, the effect of vitamin D on BMD, serum OPG and RANKL were only secondary endpoints, most of the included subjects were not vitamin D deficient, and serum 1,25(OH)2D was not measured.

Regulation (effect) of serum OPG

5) Confidence 0.07 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.35 Pain Relevance 0.04

Regulation of osteoprotegerin pro- or anti-tumoral activity by bone tumor microenvironment.

Regulation (Regulation) of osteoprotegerin associated with bone cancer

6) Confidence 0.03 Published 2010 Journal Biochim. Biophys. Acta Section Title Doc Link 19733222 Disease Relevance 0.98 Pain Relevance 0.09

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