INT162793

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.61
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2)
cytoplasm (NOD2)
Anatomy Link Frequency
fibroblasts 1
NOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
Crohn's disease 106 99.72 Very High Very High Very High
Inflammation 71 99.28 Very High Very High Very High
Inflammatory mediators 5 97.24 Very High Very High Very High
pulpitis 2 93.32 High High
cytokine 15 91.84 High High
tolerance 4 83.12 Quite High
chemokine 1 77.80 Quite High
Bile 4 73.76 Quite High
agonist 3 71.20 Quite High
Disease Link Frequency Relevance Heat
Disease 146 99.72 Very High Very High Very High
Repression 16 99.68 Very High Very High Very High
Genetic Predisposition To Disease 6 99.60 Very High Very High Very High
INFLAMMATION 66 99.28 Very High Very High Very High
Inflammatory Bowel Disease 54 96.84 Very High Very High Very High
Biliary Liver Cirrhosis 30 96.28 Very High Very High Very High
Primary Sclerosing Cholangitis 42 95.84 Very High Very High Very High
Pulpitis 2 93.32 High High
Crohn's Disease 24 91.32 High High
Disease Susceptibility 6 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This additional regulatory mechanism may to contribute to the overall control of NOD2 protein level in inflammation.
Regulation (control) of NOD2 associated with inflammation
1) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.57 Pain Relevance 0.26
stimulation all result in a higher sensitivity of the cellular NOD2 sensor function.
Regulation (sensitivity) of NOD2
2) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.41 Pain Relevance 0.13
The salient finding of the present study is the demonstration of two novel exons (exon1a and 1b) in the NOD2/CARD15 gene, which appear to contribute to the tight regulation of NOD2 protein levels in the physiological setting.
Regulation (regulation) of NOD2
3) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.09 Pain Relevance 0
It will be a major goal to dissect the contribution of the differential usage of the two alternative promoters in different cell types and the regulation of the uORF-mediated translational repression to the overall control of NOD2 protein level.
Regulation (control) of NOD2 associated with repression
4) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.44 Pain Relevance 0.13
It has been reported that the genetic predisposition to CD is caused by alterations in several genes, including NOD2/CARD15, OCTN1, OCTN2, DLG, ATG16L1 and IL23R [11-14].
Regulation (alterations) of CARD15 associated with crohn's disease and genetic predisposition to disease
5) Confidence 0.26 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 2.80 Pain Relevance 0.35
It has been reported that the genetic predisposition to CD is caused by alterations in several genes, including NOD2/CARD15, OCTN1, OCTN2, DLG, ATG16L1 and IL23R [11-14].
Regulation (alterations) of NOD2 associated with crohn's disease and genetic predisposition to disease
6) Confidence 0.25 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 2.79 Pain Relevance 0.35
Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.
Regulation (Roles) of NOD2 in fibroblasts associated with cox2
7) Confidence 0.11 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55

General Comments

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