INT162793

Context Info Confidence 0.45 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 7.61 Pain Relevance 1.78

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2) cytoplasm (NOD2)

Anatomy Link Frequency fibroblasts 1 NOD2 (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 1 100.00 Crohn's disease 106 99.72 Inflammation 71 99.28 Inflammatory mediators 5 97.24 pulpitis 2 93.32 cytokine 15 91.84 tolerance 4 83.12 chemokine 1 77.80 Bile 4 73.76 agonist 3 71.20

Disease Link Frequency Relevance Heat Disease 146 99.72 Repression 16 99.68 Genetic Predisposition To Disease 6 99.60 INFLAMMATION 66 99.28 Inflammatory Bowel Disease 54 96.84 Biliary Liver Cirrhosis 30 96.28 Primary Sclerosing Cholangitis 42 95.84 Pulpitis 2 93.32 Crohn's Disease 24 91.32 Disease Susceptibility 6 91.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This additional regulatory mechanism may to contribute to the overall control of NOD2 protein level in inflammation.

Regulation (control) of NOD2 associated with inflammation

1) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.57 Pain Relevance 0.26

stimulation all result in a higher sensitivity of the cellular NOD2 sensor function.

Regulation (sensitivity) of NOD2

2) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.41 Pain Relevance 0.13

The salient finding of the present study is the demonstration of two novel exons (exon1a and 1b) in the NOD2/CARD15 gene, which appear to contribute to the tight regulation of NOD2 protein levels in the physiological setting.

Regulation (regulation) of NOD2

3) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.09 Pain Relevance 0

It will be a major goal to dissect the contribution of the differential usage of the two alternative promoters in different cell types and the regulation of the uORF-mediated translational repression to the overall control of NOD2 protein level.

Regulation (control) of NOD2 associated with repression

4) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.44 Pain Relevance 0.13

It has been reported that the genetic predisposition to CD is caused by alterations in several genes, including NOD2/CARD15, OCTN1, OCTN2, DLG, ATG16L1 and IL23R [11-14].

Regulation (alterations) of CARD15 associated with crohn's disease and genetic predisposition to disease

5) Confidence 0.26 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 2.80 Pain Relevance 0.35

It has been reported that the genetic predisposition to CD is caused by alterations in several genes, including NOD2/CARD15, OCTN1, OCTN2, DLG, ATG16L1 and IL23R [11-14].

Regulation (alterations) of NOD2 associated with crohn's disease and genetic predisposition to disease

6) Confidence 0.25 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 2.79 Pain Relevance 0.35

Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.

Regulation (Roles) of NOD2 in fibroblasts associated with cox2

7) Confidence 0.11 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55

General Comments

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