INT162911

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE3A) signal transduction (PDE3A) lipid metabolic process (PDE3A)
Anatomy Link Frequency
endothelial cells 2
myocardium 1
smooth muscle 1
PDE3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 97.20 Very High Very High Very High
cINOD 3 83.44 Quite High
fibrosis 3 77.92 Quite High
Inflammatory mediators 12 69.88 Quite High
antagonist 3 34.08 Quite Low
chemokine 3 29.88 Quite Low
cytokine 3 29.40 Quite Low
headache 5 10.00 Low Low
adenocard 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 93 98.48 Very High Very High Very High
Asthma 6 98.16 Very High Very High Very High
INFLAMMATION 132 97.20 Very High Very High Very High
Obesity 6 95.80 Very High Very High Very High
Adhesions 3 80.00 Quite High
Fibrosis 3 77.92 Quite High
Necrosis 3 71.64 Quite High
Cancer 3 71.28 Quite High
Bronchitis 3 56.08 Quite High
Nicotine Addiction 9 55.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE3 is present in T lymphocytes, macrophages, monocytes as well as in airway smooth muscle and endothelial cells (Schudt et al 1995; Torphy 1998).
Gene_expression (present) of PDE3 in smooth muscle
1) Confidence 0.24 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 1.16 Pain Relevance 0.33
PDE3A is found in myocardium, arterial, venous, bronchial, and gastrointestinal smooth muscle, while PDE3B is found in adipose tissue (Reinhardt et al 1995).
Gene_expression (found) of PDE3A in myocardium associated with obesity
2) Confidence 0.20 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.15 Pain Relevance 0
PDE3 is present in T lymphocytes, macrophages, monocytes as well as in airway smooth muscle and endothelial cells (Schudt et al 1995; Torphy 1998).
Gene_expression (present) of PDE3 in endothelial cells
3) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 1.16 Pain Relevance 0.33
The presence of PDE3 or PDE5 in endothelial cells indicates that selective inhibitors may have functional effects in such cells.
Gene_expression (presence) of PDE3 in endothelial cells
4) Confidence 0.06 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0

General Comments

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