INT163052

Context Info Confidence 0.38 First Reported 2006 Last Reported 2010 Negated 0 Speculated 4 Reported most in Body Documents 11 Total Number 15 Disease Relevance 1.21 Pain Relevance 6.31

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn) cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)

Anatomy Link Frequency MSN 3 synapses 3 DA neuron 1 dendritic tree 1 Msn (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pyramidal cell 336 100.00 Dopamine 1127 99.98 Serotonin 28 99.98 Nucleus accumbens 344 99.88 GABAergic 85 99.20 monoamine 25 98.22 dopamine receptor 39 98.20 agonist 148 97.68 imagery 32 96.88 Action potential 57 94.16

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 212 98.68 Parkinson's Disease 20 70.24 Drug Dependence 4 52.04 Disease 4 49.68 Cognitive Disorder 4 25.44 Depression 7 24.68 Arrhythmias 2 Under Development 7 21.92 Anaerobic Bacterial Infections 14 5.00 Decapitation 12 5.00 Hypersensitivity 12 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the shell of the Acb, the dimensions of the dendritic tree of MSN ranged from 62 up to 375 ?

Regulation (dimensions) of MSN in dendritic tree associated with nucleus accumbens and pyramidal cell

1) Confidence 0.38 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0.07 Pain Relevance 0.56

The dimensions of the extending recurrent axon collaterals of MSN ranged from 275 up to 575 ?

Regulation (dimensions) of MSN associated with pyramidal cell

2) Confidence 0.38 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0.10 Pain Relevance 0.53

So, both D1- and D2-like receptors appear to be present presynaptically and are thus positioned to modulate MSN synapses.

Regulation (modulate) of MSN in synapses

3) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.33 Pain Relevance 0.45

Here, using perforated patch-clamp recordings, we investigated the alterations in MSN intrinsic excitability induced by dopamine depletion.

Spec (investigated) Regulation (alterations) of MSN in MSN associated with dopamine

4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.05 Pain Relevance 0.17

As stated in the introduction, although the consequences of dopamine receptors activation on striatal neurons physiology have been the subject of numerous studies, the alterations of MSN intrinsic excitability resulting from dopamine depletion remain incompletely documented.

Regulation (alterations) of MSN in neurons associated with dopamine and dopamine receptor

5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.07 Pain Relevance 0.23

As same changes were detected in dopamine depletion, this strongly suggests a pivotal, if not exclusive, role of this current in the alterations in MSN intrinsic excitability observed in this condition.

Regulation (alterations) of MSN associated with dopamine

6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.32

This was not due to DA acting via other monoaminergic receptors [viz. [57]], as there were clear instances where norepinephrine and serotonin modulated MSN synaptic connections that showed modest DA modulation.

Regulation (modulated) of MSN associated with dopamine, serotonin and monoamine

7) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 1.11

Presynaptic D2 autoreceptors on DA neuron terminals inhibit DA release [71], D2 heteroreceptors on corticostriatal terminals inhibit glutamatergic inputs [72], and presynaptic D1 and D2 heteroreceptors on MSN terminals modulate GABAergic IPSCs [present results, and Refs. [9,73]].

Regulation (heteroreceptors) of MSN in DA neuron associated with dopamine and gabaergic

8) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.22 Pain Relevance 0.58

In postnatal nAcc cultures, we examined MSN-to-MSN synaptic connections and their modulation by DA.

Spec (examined) Regulation (modulation) of MSN associated with dopamine

9) Confidence 0.30 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.15 Pain Relevance 0.23

MSN activity is also altered by acute exposure to psychostimulants and other dopamine agonists (Tschanz et al., 1991; Haracz et al., 1993; Pederson et al., 1997; Rebec et al., 1997; West et al., 1997; White and Kalivas, 1998).

Regulation (altered) of MSN associated with dopamine and agonist

10) Confidence 0.20 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC3017361 Disease Relevance 0 Pain Relevance 0.19

Moreover, a D2 receptor-mediated regulation of this current in MSN has been suggested previously [21], [22].

Regulation (regulation) of MSN

11) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.34

Our paired-pulse experiments provide evidence for presynaptic modulation of MSN-to-MSN connections in culture.

Regulation (modulation) of MSN

12) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.08 Pain Relevance 0.44

To examine DA modulation of individual MSN-to-MSN synapses, and to address the hypothesis that DA receptors show differential trafficking, we used postnatal cell culture to gain access to individual, identified MSN synapses.

Spec (examine) Regulation (modulation) of MSN in synapses associated with dopamine

13) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.07 Pain Relevance 0.53

To examine DA modulation of individual MSN-to-MSN synapses, and to address the hypothesis that DA receptors show differential trafficking, we used postnatal cell culture to gain access to individual, identified MSN synapses.

Spec (examine) Regulation (modulation) of MSN in synapses associated with dopamine

14) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.07 Pain Relevance 0.53

We have used inhibitors of PDE10A and quantitative measures of mRNA to demonstrate that PDE10A controls striatal gene expression by regulating MSN cyclic nucleotide signaling pathways.

Regulation (regulating) of MSN in MSN

15) Confidence 0.08 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.11

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