INT163054

Context Info Confidence 0.66 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 20 Total Number 24 Disease Relevance 0.60 Pain Relevance 9.06

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn) cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)

Anatomy Link Frequency dendrites 4 neurons 3 synapses 3 MSNs 2 ventral 2 Msn (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pyramidal cell 1680 100.00 Nucleus accumbens 1491 100.00 projection neuron 475 100.00 Enkephalin 305 100.00 Dopamine 918 99.84 substance P 244 99.72 GABAergic 113 97.24 Neuropeptide 2 96.44 agonist 68 95.88 Action potential 137 93.60

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 100 100.00 Targeted Disruption 11 98.44 Neurological Disease 1 97.94 Parkinson's Disease 50 56.40 Depression 4 38.16 Congenital Anomalies 3 18.40 Decapitation 12 5.00 Hypersensitivity 12 5.00 Disease 11 5.00 Volume Depletion And Dehydration 10 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of the present study confirm these observations in showing that in the core of the Acb axons of labeled MSN may enter and terminate in a nearby patch.

Gene_expression (axons) of MSN associated with nucleus accumbens and pyramidal cell

1) Confidence 0.66 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.36

5 subunit is more expressed in the D2- than in the D1-MSNs (Ade et al., 2008).

Gene_expression (expressed) of MSN associated with projection neuron

2) Confidence 0.65 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.54

Figure 4 shows that a similar percentage of the corticostriatal response was enhanced in both neuronal classes during L655-708: ca. 37% and 35% for D1-SP+ and D2-ENK+ MSNs, respectively (n?

Gene_expression (respectively) of MSN in neuronal associated with projection neuron, enkephalin and substance p

3) Confidence 0.65 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.68

Bicuculline actions in D2-ENK+ MSNs can be explained by the distinct and higher dendritic excitability present in these neurons (Galarraga et al., 1997; Day et al., 2008): even when inhibition is also depolarizing, it has the role of restraining stronger depolarizing intrinsic currents (shunting inhibition) (Bartos et al., 2007).

Gene_expression (explained) of MSN in neurons associated with projection neuron and enkephalin

4) Confidence 0.65 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.21

Based on work with bacterial artificial chromosome (BAC) transgenic mice, here it is shown that corticostriatal responses in D1- and D2-receptor expressing MSNs (D1- and D2-MSNs) are radically different so as to establish an electrophysiological footprint that readily differentiates between them.

Gene_expression (expressing) of MSN in MSNs associated with targeted disruption and projection neuron

5) Confidence 0.58 Published 2010 Journal Frontiers in Systems Neuroscience Section Abstract Doc Link PMC2893005 Disease Relevance 0.10 Pain Relevance 0.67

It must be emphasized, however, that intercompartmental connections on the basis of MSN projections are scarce and intercompartmental connections might be more prominent for interneurons with long axon collaterals, such as cholinergic (Meredith et al. 1989; Kawaguchi 1993) and somatostatin interneurons (Chesselet and Graybiel 1986).

Gene_expression (projections) of MSN in interneurons associated with pyramidal cell and somatostatin

6) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.38

Principally, three patterns were distinguished: (1) MSN with a distribution of axon collaterals largely falling within the space of the dendritic distribution (‘full overlap’); (2) MSN with axonal collaterals extending beyond the reaches of the dendritic arborizations, but with a considerable degree of overlap (‘partial overlap’); (3) MSN with recurrent axon collaterals occupying a 3D-space that showed no or only minimal overlap with the dendrites of the same neuron (no overlap).

Gene_expression (distinguished) of MSN in dendrites associated with pyramidal cell

7) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.39

Whether MSN with longer ranging axon collaterals exist within the Acb shell remains uncertain; the present sample of juxtacellulary filled neurons does not include neurons of that category.

Gene_expression (shell) of MSN in neurons associated with nucleus accumbens and pyramidal cell

8) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.30

Principally, three patterns were distinguished: (1) MSN with a distribution of axon collaterals largely falling within the space of the dendritic distribution (‘full overlap’); (2) MSN with axonal collaterals extending beyond the reaches of the dendritic arborizations, but with a considerable degree of overlap (‘partial overlap’); (3) MSN with recurrent axon collaterals occupying a 3D-space that showed no or only minimal overlap with the dendrites of the same neuron (no overlap).

Gene_expression (distinguished) of MSN in dendrites associated with pyramidal cell

9) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.37

An example of an MSN located in the matrix compartment with a dorsal–medial to ventral–lateral dendritic orientation is illustrated in Fig. 4.

Gene_expression (example) of MSN in ventral associated with pyramidal cell

10) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.57

Principally, three patterns were distinguished: (1) MSN with a distribution of axon collaterals largely falling within the space of the dendritic distribution (‘full overlap’); (2) MSN with axonal collaterals extending beyond the reaches of the dendritic arborizations, but with a considerable degree of overlap (‘partial overlap’); (3) MSN with recurrent axon collaterals occupying a 3D-space that showed no or only minimal overlap with the dendrites of the same neuron (no overlap).

Gene_expression (distinguished) of MSN in dendrites associated with pyramidal cell

11) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.36

The red dots represent MSN with a dorsal-medial to ventral-lateral orientation (again schematically indicated with the line through the dot).

Gene_expression (represent) of MSN in ventral associated with pyramidal cell

12) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.58

Indications for patch-matrix communication on the basis of axon collaterals of the MSN projection neurons have been very sparse until now.

Gene_expression (projection neurons) of MSN in projection neurons associated with pyramidal cell

13) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.29

However, the present study extends these observations by showing that MSN in either of these two larger subregions of the Acb, i.e., the shell and core, likewise retain their dendrites within the subregion in which the cell body resides.

Gene_expression (subregions) of MSN in dendrites associated with nucleus accumbens and pyramidal cell

14) Confidence 0.57 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.37

Moreover, the slope of the ramp potential evoked by a subthreshold depolarizing current pulse was significantly higher for MSN in 6-OHDA lesioned animals (0.021±0.0023 mV/ms, n?

Gene_expression (higher) of MSN

15) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.07

The slope of the ramp potential was significantly higher for MSN in dopamine-depleted animals (0.023±0.003 mV/ms, n?

Gene_expression (higher) of MSN associated with dopamine

16) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.06 Pain Relevance 0.39

The evaluation of the slope factor of the linear part of stimulation-EPSP slope plots was used as a parameter of the strength of the excitatory fiber – MSN synapse (Fig. 6C, Da).

Gene_expression (synapse) of MSN in synapse

17) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.26

Moreover, this first direct demonstration of the involvement of IA regulation in dopamine depletion strongly emphasizes the importance of this current in MSN intrinsic excitability.

Gene_expression (excitability) of MSN associated with dopamine

18) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.30

Nonetheless, we focused on autaptic responses, because they provided access to single identified MSN-to-MSN synapses.

Gene_expression (synapses) of MSN in synapses

19) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.19

Since DA agonists produced at most a reduction to 50% inhibition of control GABAergic IPSCs (see previous section), while some varicosities showed arrest of FM1-43 destaining (0% of control), this suggests that a subset of MSN varicosities express DA receptors that may shut down release.

Gene_expression (varicosities) of MSN associated with dopamine, gabaergic, agonist and increased venous pressure under development

20) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.34 Pain Relevance 0.45

General Comments

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