INT163253

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.60
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Flg) cytoskeleton organization (Flg)
Anatomy Link Frequency
skin 2
immune system 1
Flg (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 96.48 Very High Very High Very High
cytokine 11 95.32 Very High Very High Very High
Inflammatory response 5 90.56 High High
Inflammation 17 73.52 Quite High
headache 1 30.04 Quite Low
agonist 3 27.52 Quite Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Francisella Infection 58 100.00 Very High Very High Very High
Ichthyosis Vulgaris 6 100.00 Very High Very High Very High
Eczema 2 99.76 Very High Very High Very High
Sprains And Strains 38 96.40 Very High Very High Very High
Ichthyosis 2 91.12 High High
Pachyonychia Congenita 12 91.08 High High
INFLAMMATION 22 90.20 High High
Alopecia Areata 2 89.92 High High
Infection 47 88.24 High High
Death 3 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV), which presents with generalized scaling and is also associated with atopic dermatitis.
FLG Binding (associated) of in skin associated with ichthyosis vulgaris and eczema
1) Confidence 0.31 Published 2009 Journal Br. J. Dermatol. Section Abstract Doc Link 19785597 Disease Relevance 0.90 Pain Relevance 0.10
Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV), which presents with generalized scaling and is also associated with atopic dermatitis.
filaggrin Binding (associated) of in skin associated with ichthyosis vulgaris and eczema
2) Confidence 0.31 Published 2009 Journal Br. J. Dermatol. Section Abstract Doc Link 19785597 Disease Relevance 0.90 Pain Relevance 0.10
Interaction of Ft with cells of the innate immune system (macrophages, dendritic cells, neutrophils, NK cells) initiates a cascade of cytokine production including IFN-?
Ft Binding (Interaction) of in immune system associated with francisella infection and cytokine
3) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.80 Pain Relevance 0.13

General Comments

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