INT16326

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Context Info
Confidence 0.71
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 58
Total Number 58
Disease Relevance 15.78
Pain Relevance 20.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 6
striatum 5
globus pallidus 3
basal ganglia 3
CeA 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 63 100.00 Very High Very High Very High
Glutamate 35 100.00 Very High Very High Very High
Dynorphin 31 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
dopamine receptor 11 100.00 Very High Very High Very High
GABAergic 398 99.92 Very High Very High Very High
Neuropeptide 24 99.92 Very High Very High Very High
Nucleus accumbens 31 99.84 Very High Very High Very High
gABA 164 99.74 Very High Very High Very High
Hippocampus 15 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 504 100.00 Very High Very High Very High
Disease 145 99.84 Very High Very High Very High
Dyskinesias 182 99.56 Very High Very High Very High
Parkinson's Disease 93 98.90 Very High Very High Very High
Stress 33 97.72 Very High Very High Very High
Nociception 7 96.44 Very High Very High Very High
Neuropathic Pain 8 89.32 High High
Hyperkinesis 1 88.64 High High
Frailty 1 87.04 High High
Eating Disorder 3 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the L-DOPA-treated group, levels of preproenkephalin (PPE) mRNA, glutamic acid decarboxylase (GAD67) mRNA, and prodynorphin (PDyn) mRNA in the dopamine-denervated caudate-putamen, as well as GAD67 mRNA expression in the globus pallidus ipsilateral to the 6-hydroxydopamine (6-OHDA) lesion, were higher in dyskinetic than non-dyskinetic animals, and positively correlated with the rats' dyskinesia scores.
Transcription (levels) of GAD67 in globus pallidus associated with dopamine and dyskinesias
1) Confidence 0.71 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.32 Pain Relevance 0.12
Within the L-DOPA-treated group, levels of preproenkephalin (PPE) mRNA, glutamic acid decarboxylase (GAD67) mRNA, and prodynorphin (PDyn) mRNA in the dopamine-denervated caudate-putamen, as well as GAD67 mRNA expression in the globus pallidus ipsilateral to the 6-hydroxydopamine (6-OHDA) lesion, were higher in dyskinetic than non-dyskinetic animals, and positively correlated with the rats' dyskinesia scores.
Transcription (levels) of glutamic acid decarboxylase in globus pallidus associated with dopamine and dyskinesias
2) Confidence 0.71 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.32 Pain Relevance 0.12
Thereafter, changes in the expression of glutamic acid decarboxylase (GAD)67 mRNA were estimated by in situ hybridization in the central nucleus of the amygdala (CeA), basolateral amygdala (BLA), dorsolateral striatum (dLStr), nucleus accumbens shell (AcS) and core (AcC).
Transcription (expression) of glutamic acid decarboxylase in CeA associated with nucleus accumbens, generalized anxiety disorder and amygdala
3) Confidence 0.71 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.42 Pain Relevance 0.61
CB(1) mRNA was localized to putative GABAergic interneurons that express high levels of GAD67 mRNA.
Transcription (express) of GAD67 in interneurons associated with gabaergic
4) Confidence 0.69 Published 2000 Journal Synapse Section Abstract Doc Link 10842353 Disease Relevance 0 Pain Relevance 0.38
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Transcription (levels) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
5) Confidence 0.68 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.08 Pain Relevance 0.36
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Transcription (levels) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
6) Confidence 0.68 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.08 Pain Relevance 0.36
Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum.
Transcription (expression) of GAD67 in striatum associated with glutamate, dopamine and deafferentation
7) Confidence 0.68 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.38
The rat nucleus accumbens: two levels of complexity in the distribution of glutamic acid decarboxylase (67 kDa) and preproenkephalin messenger RNA.
Transcription (distribution) of glutamic acid decarboxylase in nucleus accumbens associated with nucleus accumbens and enkephalin
8) Confidence 0.68 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8361669 Disease Relevance 0 Pain Relevance 0.54
Within the L-DOPA-treated group, levels of preproenkephalin (PPE) mRNA, glutamic acid decarboxylase (GAD67) mRNA, and prodynorphin (PDyn) mRNA in the dopamine-denervated caudate-putamen, as well as GAD67 mRNA expression in the globus pallidus ipsilateral to the 6-hydroxydopamine (6-OHDA) lesion, were higher in dyskinetic than non-dyskinetic animals, and positively correlated with the rats' dyskinesia scores.
Transcription (expression) of GAD67 mRNA in globus pallidus associated with dopamine and dyskinesias
9) Confidence 0.68 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.38 Pain Relevance 0.12
However, a multiple regression equation including the three factors, GAD67 mRNA levels in the GP, GAD67 mRNA in the lateral CPu, and striatal PDyn mRNA, gave a better fit for dyskinesia scores than PDyn mRNA alone (r2 = 0.92).
Transcription (gave) of GAD67 mRNA in lateral associated with dyskinesias
10) Confidence 0.68 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.59 Pain Relevance 0.12
However, a multiple regression equation including the three factors, GAD67 mRNA levels in the GP, GAD67 mRNA in the lateral CPu, and striatal PDyn mRNA, gave a better fit for dyskinesia scores than PDyn mRNA alone (r2 = 0.92).
Transcription (gave) of GAD67 mRNA in lateral associated with dyskinesias
11) Confidence 0.68 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.58 Pain Relevance 0.12
Moreover, high frequency EA reversed the axotomy-induced decrease in substance P content and increase in glutamate decarboxylase-67 (GAD 67) mRNA level in the midbrain; however, it did not affect the axotomy-induced increase in enkephalin content in the globus pallidus.
Transcription (level) of glutamate decarboxylase-67 in midbrain associated with glutamate, generalized anxiety disorder, enkephalin, midbrain, acupuncture and substance p
12) Confidence 0.68 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19549545 Disease Relevance 0.34 Pain Relevance 0.63
Moreover, high frequency EA reversed the axotomy-induced decrease in substance P content and increase in glutamate decarboxylase-67 (GAD 67) mRNA level in the midbrain; however, it did not affect the axotomy-induced increase in enkephalin content in the globus pallidus.
Transcription (level) of GAD 67 in midbrain associated with glutamate, generalized anxiety disorder, enkephalin, midbrain, acupuncture and substance p
13) Confidence 0.68 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19549545 Disease Relevance 0.34 Pain Relevance 0.62
Opioid peptides mRNA in the dorsolateral striatum (dlStr) and glutamic acid decarboxylase (GAD67) mRNA content in globus pallidus (GP), were evaluated as an index of neuroadaptive changes occurring in the direct and indirect basal ganglia pathways.
Transcription (content) of glutamic acid decarboxylase in basal ganglia associated with opioid
14) Confidence 0.68 Published 2008 Journal Synapse Section Abstract Doc Link 18435422 Disease Relevance 0.65 Pain Relevance 0.37
Opioid peptides mRNA in the dorsolateral striatum (dlStr) and glutamic acid decarboxylase (GAD67) mRNA content in globus pallidus (GP), were evaluated as an index of neuroadaptive changes occurring in the direct and indirect basal ganglia pathways.
Transcription (content) of GAD67 in basal ganglia associated with opioid
15) Confidence 0.68 Published 2008 Journal Synapse Section Abstract Doc Link 18435422 Disease Relevance 0.65 Pain Relevance 0.37
These studies found that the number of neurons expressing GAD67 mRNA is significantly less than the number of neurons expressing GAD67 protein [21], suggesting that for this protein immunohistochemistry may be more reliable than mRNA detection.
Transcription (expressing) of GAD67 in neurons
16) Confidence 0.66 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 1.01 Pain Relevance 0.53
For instance, a number of studies using in situ hybridization studies have unraveled changes in glutamic acid decarboxylase (GAD) mRNA levels, the rate-limiting enzyme in the synthesis of GABA, in parkinsonian and dyskinetic animal models.
Transcription (levels) of glutamic acid decarboxylase associated with parkinson's disease, gaba and generalized anxiety disorder
17) Confidence 0.60 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.65 Pain Relevance 0.09
Striatal glutamic acid decarboxylase mRNA levels in PD and LID
Transcription (levels) of glutamic acid decarboxylase associated with disease and dyskinesias
18) Confidence 0.60 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.37 Pain Relevance 0.04
In contrast, only a small percentage of the numerous Fos-labeled neurons localized in the mammillary hypothalamus expressed GAD67 mRNA.
Transcription (expressed) of GAD67 in hypothalamus
19) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.75 Pain Relevance 0.05
Although it was suspected, we further provide the first direct demonstration that most of the MCH neurons (85%) express GAD67 mRNA.
Transcription (express) of GAD67 in neurons
20) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.16 Pain Relevance 0.36

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