INT163262

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.81
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
adipocyte 1
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 94.08 High High
imagery 2 70.04 Quite High
tolerance 20 51.04 Quite High
agonist 2 50.00 Quite Low
Somatostatin 2 50.00 Quite Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 150 99.20 Very High Very High Very High
INFLAMMATION 43 94.08 High High
Lipodystrophy 44 85.08 High High
Myocardial Infarction 3 81.92 Quite High
Syndrome 8 75.00 Quite High
Frailty 3 71.48 Quite High
Insulin Resistance 28 69.52 Quite High
Impaired Glucose Tolerance 19 51.04 Quite High
Aging 2 46.96 Quite Low
Hyperinsulinism 3 46.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adiponectin mRNA expression was also reduced but leptin mRNA levels were unaltered.
Transcription (expression) of Adiponectin
1) Confidence 0.52 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2533346 Disease Relevance 1.26 Pain Relevance 0.05
A state of adiponectin resistance
    was recently described in insulin resistant mice with hyperadiponectinemia with normal levels
    of adiponectin receptor-1 and -2 and inability to lower glucose levels by adiponectin
    administration 22. 
Transcription (described) of adiponectin
2) Confidence 0.48 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.58 Pain Relevance 0.04
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
Transcription (detect) of adiponectin
3) Confidence 0.44 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
Subsequently, another link between the adipocyte and the complement system was apparent with the description of adiponectin, an adipocyte-specific product that is highly homologous to C1q (38).
Transcription (description) of adiponectin in adipocyte
4) Confidence 0.15 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.98 Pain Relevance 0.03
Upregulation of PPARG expression is induced during mitotic arrest very early in adipose differentiation and stimulates the adipogenic pathway, activating the transcription of other adipose-specific genes [32]–[34].
Transcription (transcription) of adipose-specific
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0.04

General Comments

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