INT163364

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.91 Pain Relevance 0.62

endosome (Mmd)

Thim (Mus musculus) Mmd (Rattus norvegicus) Thim - L823R (1)

Pain Link Frequency Relevance Heat nociceptor 2 91.76 Nav1.7 3 89.92 sodium channel 2 89.64 burning pain 1 82.36 Neuropathic pain 1 80.48

Disease Link Frequency Relevance Heat Erythermalgia 8 95.40 Increased Venous Pressure Under Development 1 85.04 Pain 1 82.36 Syndrome 1 80.84 Neuropathic Pain 1 80.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The L823R mutation produces an approximately 15mV hyperpolarizing shift in the midpoint of activation and also affects the activation slope factor.

mutation (L823R) Regulation (affects) of activation slope factor

1) Confidence 0.00 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19800314 Disease Relevance 0.91 Pain Relevance 0.62

General Comments

This test has worked.