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Context Info
Confidence 0.28
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.88
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
liver 1
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 76.32 Quite High
Paracetamol 4 75.00 Quite High
Glutamate 2 70.76 Quite High
tolerance 4 67.08 Quite High
Inflammation 19 57.84 Quite High
COX-2 inhibitor 2 50.00 Quite Low
cINOD 2 50.00 Quite Low
cytokine 8 49.08 Quite Low
Arthritis 1 44.96 Quite Low
Inflammatory mediators 2 27.68 Quite Low
Disease Link Frequency Relevance Heat
Leukocytosis 2 99.16 Very High Very High Very High
Injury 9 94.64 High High
Toxicity 15 83.04 Quite High
Neuropathic Pain 1 82.24 Quite High
Diabetes Mellitus 81 76.64 Quite High
Pain 2 76.32 Quite High
Jaundice 1 75.84 Quite High
Hepatotoxicity 14 75.00 Quite High
Hypertension 1 73.96 Quite High
Heart Rate Under Development 1 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enzymes such as ALT, AST, ACP and ALP are responsible for the proper functioning of the liver and any damages induced in the liver due to the hyperglycemic conditions may lead to excessive leakage of these enzymes in the blood stream.
Regulation (responsible) of ALP in blood
1) Confidence 0.28 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.48 Pain Relevance 0.03
Effects on alkaline phosphatase (ALP) activity and osteocalcin were not clearly demonstrated.
Regulation (Effects) of ALP
2) Confidence 0.21 Published 2008 Journal Int J Oral Maxillofac Implants Section Body Doc Link 19216276 Disease Relevance 0 Pain Relevance 0
The same dose of plant extract (500 mg/kg) was able to significantly prevent (P < 0.05) CCl4-induced rise in serum enzymes and the estimated values of ALP, GOT and GPT were 220 +/- 30, 207 +/- 95 and 75 +/- 38, respectively. 7.
Regulation (values) of ALP
3) Confidence 0.06 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.20 Pain Relevance 0.32
The values of ALP, ASAT, and ALAT became normal some days later.
Regulation (values) of ALP
4) Confidence 0.04 Published 1991 Journal Lakartidningen Section Abstract Doc Link 1825862 Disease Relevance 0.84 Pain Relevance 0.08
No significant changes in liver enzyme activities (ALT, AST, GGT, ALP) were evident.
Neg (No) Regulation (changes) of ALP in liver
5) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000109 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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