INT163506

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 19 98.08 Very High Very High Very High
Paracetamol 60 96.16 Very High Very High Very High
antidepressant 11 95.28 Very High Very High Very High
bDMF 16 83.44 Quite High
Raphe 1 73.40 Quite High
Serotonin 3 71.20 Quite High
Hippocampus 10 57.12 Quite High
carbamazepine 9 52.20 Quite High
Eae 2 48.00 Quite Low
fluoxetine 3 33.20 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 98.56 Very High Very High Very High
Depression 22 98.08 Very High Very High Very High
Aging 38 95.20 Very High Very High Very High
Stress 9 83.44 Quite High
Urological Neuroanatomy 11 75.00 Quite High
Shock 1 53.60 Quite High
Hyperinsulinism 1 38.36 Quite Low
Attention Deficit Hyperactivity Disorder 2 25.00 Low Low
Manic Depressive Disorder 125 15.36 Low Low
Apoptosis 14 7.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important factor in the pathogenesis of depression, and that this enzyme also contributes to the mechanism of antidepressant drug action.
GSK-3 Binding (hyperactive) of associated with antidepressant and depression
1) Confidence 0.32 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.52 Pain Relevance 0.23
It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important factor in the pathogenesis of depression, and that this enzyme also contributes to the mechanism of antidepressant drug action.
glycogen synthase kinase-3 Binding (hyperactive) of associated with antidepressant and depression
2) Confidence 0.32 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.52 Pain Relevance 0.23
After ex vivo incubation with insulin, the phosphorylation of Akt and the Akt downstream proteins, GSK-3?
GSK-3 Binding (After) of
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.10 Pain Relevance 0.55
Among the elements interacting with GSK-3?
GSK-3 Binding (interacting) of
4) Confidence 0.03 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.28 Pain Relevance 0.31

General Comments

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