INT163582

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 2.73
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tst) RNA binding (Tst) plasma membrane (Tst)
Anatomy Link Frequency
tail 1
bone marrow 1
Tst (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 17 99.68 Very High Very High Very High
withdrawal 3 99.44 Very High Very High Very High
antagonist 184 99.32 Very High Very High Very High
antidepressant 306 99.30 Very High Very High Very High
depression 92 98.60 Very High Very High Very High
agonist 33 97.00 Very High Very High Very High
Desipramine 2 86.36 High High
5HT 33 85.52 High High
fluoxetine 9 85.20 High High
Serotonin 60 84.44 Quite High
Disease Link Frequency Relevance Heat
Stress 8 99.96 Very High Very High Very High
Depression 107 98.60 Very High Very High Very High
Sprains And Strains 141 98.48 Very High Very High Very High
Disease 75 98.28 Very High Very High Very High
Hypersensitivity 3 83.40 Quite High
Lymphatic System Cancer 204 81.20 Quite High
Depressive Disorder 6 79.68 Quite High
Anxiety Disorder 21 72.32 Quite High
Affective Disorder 12 68.44 Quite High
Follicular Lymphoma 39 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, factors that increase the susceptibility to depression in humans, such as amphetamine withdrawal and chronic social stress, increase immobility in the TST (Cryan and Mombereau 2004).
Positive_regulation (increase) of TST associated with stress, depression and withdrawal
1) Confidence 0.43 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.76 Pain Relevance 0.26
It may be concluded that the extract from T. avellanedae produces an antidepressant-like effect in the FST and in the TST that is dependent on the monoaminergic system.
Positive_regulation (dependent) of TST associated with antidepressant and monoamine
2) Confidence 0.40 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 20026371 Disease Relevance 0 Pain Relevance 0.70
Of the patients with data available for analysis, 18% converted to PCR negative status after CHOP while an additional 63% converted to PCR negative status after 131I-TST.
Positive_regulation (converted) of 131I-TST
3) Confidence 0.32 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.12 Pain Relevance 0
Some studies excluded patients who had disease that progressed in field within a year after 35 Gy EBRT.13,19,20 Treatment with dose attenuated 131I-TST in patients with greater than 25% bone marrow involvement has been reported and remains investigational.21

Dosing and treatment delivery

Positive_regulation (attenuated) of 131I-TST in bone marrow associated with disease
4) Confidence 0.32 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.70 Pain Relevance 0
In contrast to B6 mice, NZB mice showed no behavioral response in either the TST or the OFT to any dose of SB-205384, supporting a specific role for the ?
Neg (no) Positive_regulation (response) of TST
5) Confidence 0.31 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.08 Pain Relevance 0.25
Diazepam significantly (p < 0.0001) increased TST immobility in both B6 (n = 5) and NZB mice (n = 7).Fig. 5Effect of GABRA3 agonist SB-205384 and GABAA agonist diazepam on TST and OFT behavior. a SB-205384 (2 mg/kg) significantly reduced TST immobility in B6 but not in NZB mice.
Positive_regulation (increased) of TST associated with agonist
6) Confidence 0.29 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.32 Pain Relevance 0.18
METHODS: Female and male transgenic mice with varying capacities to translate beta-E were subjected to either the forced swim (FST, Experiment 1) or the tail suspension test (TST, Experiment 2).
Positive_regulation (subjected) of TST in tail
7) Confidence 0.29 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 20384608 Disease Relevance 0.09 Pain Relevance 0
The 5HT2A/2C receptor antagonist, ritanserin (0.5 mg/kg), was not active in the TST when given by itself, and it did not influence the LY341495-induced attenuation of the immobility time in the TST in mice [F(1,27)?
Neg (not) Positive_regulation (active) of TST associated with antagonist
8) Confidence 0.20 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.45
MGS0039 was not active in the TST at a dose of 0.3 mg/kg.
Neg (not) Positive_regulation (active) of TST
9) Confidence 0.20 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.26
MGS0039, at a dose of 3 mg/kg, was active in the TST in both control and PCPA-pretreated mice [F(1,26)?
Positive_regulation (active) of TST
10) Confidence 0.20 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.39
For patients in CR after 131I-TST, MDR had not been reached with a median follow-up of 47 months.
Neg (not) Positive_regulation (reached) of 131I-TST
11) Confidence 0.13 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.51 Pain Relevance 0
RESULTS: While leptin and fluoxetine showed similar antidepressant-like behavioral effects in the TST and FST, they differed in the behavioral assays for anxiety.
Positive_regulation (effects) of TST
12) Confidence 0.12 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 19823809 Disease Relevance 0.14 Pain Relevance 0

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