INT163613

Context Info Confidence 0.60 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 12.98 Pain Relevance 1.62

extracellular space (CSF2) extracellular region (CSF2)

Anatomy Link Frequency plasma 3 Blood 1 cerebrospinal fluid 1 puncture 1 red blood cell 1 CSF2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 79 100.00 cytokine 57 100.00 chemokine 12 100.00 intrathecal 55 95.20 dexamethasone 44 94.12 Spinal cord 23 90.80 Central nervous system 114 90.16 Neuropathic pain 1 86.88 Neuritis 14 84.36 Migraine 21 80.40

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 408 100.00 INFLAMMATION 87 100.00 Neuropathy 5 99.92 Parkinson's Disease 155 99.86 Eosinophilia 27 99.60 Disease 284 99.50 Lumbar Puncture Related Headaches 26 99.28 Dyspnea 3 98.08 Spinocerebellar Ataxia Type 2 1 96.48 Spinal Muscular Atrophy 1 95.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Development of the CSF biophysical model

Transcription (model) of CSF

1) Confidence 0.60 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.08

In the cross-sectional evaluation, HIV RNA was characteristically lower in CSF than in plasma, and the VL differences between the two compartments, which we express here and below as the ?

Transcription (lower) of CSF in plasma associated with acquired immune deficiency syndrome or hiv infection

2) Confidence 0.58 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.59 Pain Relevance 0.05

CSF samples were thawed and 10 ?

Transcription (samples) of CSF

3) Confidence 0.58 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0 Pain Relevance 0.05

The sequence data from the virus directly detected in the CSF and from the WNV isolate from cell cultures are identical.

Transcription (detected) of CSF

4) Confidence 0.54 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2738499 Disease Relevance 0.08 Pain Relevance 0

Cross-sectionally, both ADC stages and QNPZ-4 scores correlated with blood CD4 counts, though neither correlated overall with plasma or CSF HIV RNA levels.

Transcription (levels) of CSF in plasma associated with acquired immune deficiency syndrome or hiv infection

5) Confidence 0.52 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.91 Pain Relevance 0

In comparison to PD, PDD, and AD subjects, the DLB group had the lowest CSF level of A?

Transcription (had) of CSF associated with parkinson's disease and disease

6) Confidence 0.50 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 2.33 Pain Relevance 0

CSF samples were obtained by lumbar puncture, immediately centrifuged at 450 g for five minutes at 4°C to remove cells and debris, aliquoted, and then frozen at ?

Transcription (samples) of CSF in puncture associated with lumbar puncture related headaches

7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 2.39 Pain Relevance 0.20

In July 2007, GM-CSF inhalation therapy was initiated in another hospital, but no improvement was observed.

Transcription (initiated) of GM-CSF

8) Confidence 0.46 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 19827590 Disease Relevance 0.65 Pain Relevance 0

CSF cytology, CSF white and red blood cell count, total protein, CSF to serum albumin quotient (Qalb i.e.

Transcription (serum) of CSF in red blood cell

9) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 2.03 Pain Relevance 0.36

The results of the CSF neopterin determinations on this aggregate of 741 subjects are shown in Figure 2 along with blood neopterin, CSF and plasma HIV RNA levels and CSF white blood cell (WBC) counts to provide context.

Transcription (levels) of CSF in plasma associated with acquired immune deficiency syndrome or hiv infection

10) Confidence 0.37 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.20 Pain Relevance 0.06

Blood-CSF barrier function

Transcription (function) of CSF in Blood

11) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.25 Pain Relevance 0.14

Glucocorticoids, the most effective agents for reducing eosinophilia, suppress the gene transcription of IL-3, IL-4, IL-5, GM-CSF, and various chemokines [1].

Transcription (transcription) of GM-CSF associated with chemokine and eosinophilia

12) Confidence 0.23 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.54 Pain Relevance 0.10

CVA9: Coxsackievirus A9; RT-PCR: reverse transcription-polymerase chain reaction; CSF: cerebrospinal fluid; HEV: Human Enteroviruses; CPE: cytopathic effect; IgM: immunoglobulin M.

Transcription (transcription) of CSF in cerebrospinal fluid

13) Confidence 0.18 Published 2010 Journal Virol J Section Body Doc Link PMC2907575 Disease Relevance 0.56 Pain Relevance 0.03

Ceramide activated IL-6 transcription (6.2-fold), MAP3K1 and MAP2K3 (5.9- and 2.5-fold), as well as IL-8 and CSF2 transcription levels (about 3-fold).

Transcription (transcription) of CSF2

14) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.09 Pain Relevance 0

Ceramide activated IL-6 transcription (6.2-fold), MAP3K1 and MAP2K3 (5.9- and 2.5-fold), as well as IL-8 and CSF2 transcription levels (about 3-fold).

Transcription (transcription) of CSF2

15) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.09 Pain Relevance 0

Although the glucocorticoid action in inflammatory diseases is not fully understood, it is well documented that glucocorticoids inhibit the transcription of the majority of inflammatory cytokines and chemokines involved in the inflammatory process, including eotaxin, GM-CSF, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-11, MCP-1, MIP-1, MIP-3, MIP-4, MIP-1?

Transcription (transcription) of GM-CSF associated with chemokine, inflammation, disease and cytokine

16) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.27 Pain Relevance 0.55

General Comments

This test has worked.