INT163872

Context Info Confidence 0.42 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.52 Pain Relevance 0.49

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)

Anatomy Link Frequency thyroid 4 TSHR (Homo sapiens)

Pain Link Frequency Relevance Heat Ultiva 4 88.16 anesthesia 2 76.92 Inflammation 13 52.12 Serotonin 2 18.24 cytokine 3 5.00 depression 3 5.00 Pain 3 5.00 headache 3 5.00 Acupuncture 2 5.00 drug abuse 2 5.00

Disease Link Frequency Relevance Heat Thyroid Disease 34 99.26 Hyperemesis Gravidarum 53 98.64 Graves' Ophthalmopathy 31 97.28 Heart Rate Under Development 3 96.56 Arrhythmias 2 Under Development 3 95.92 Hyperthyroidism 5 92.32 Autoimmune Disease 22 91.76 Muscle Disease 12 89.60 Disorder Of Lipid Metabolism 3 84.92 Graves Disease 1 84.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further investigations revealed an elevated serum free thyroxin level and suppressed thyroid-stimulating hormone (TSH).

Negative_regulation (suppressed) of thyroid-stimulating hormone in thyroid

1) Confidence 0.42 Published 2009 Journal Masui Section Abstract Doc Link 19860236 Disease Relevance 1.00 Pain Relevance 0.46

This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies.

Negative_regulation (effect) of TSH-r in thyroid

2) Confidence 0.39 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.77 Pain Relevance 0.03

Lithium has been found to interfere with the production of thyroid hormones including the inhibition of the thyroid stimulating hormone (TSH)-responsive adenylate cyclase and PKC in thyroid cells [22-24].

Negative_regulation (inhibition) of thyroid stimulating hormone in thyroid

3) Confidence 0.17 Published 2008 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2531078 Disease Relevance 0.53 Pain Relevance 0

Hyperthyroidism with normal fT3 and fT4 levels, but decreased levels of thyroid stimulating hormone (TSH), may also be implicated in HG [37,38].

Negative_regulation (decreased) of thyroid stimulating hormone in thyroid associated with thyroid disease and hyperemesis gravidarum

4) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2913953 Disease Relevance 1.23 Pain Relevance 0

General Comments

This test has worked.