INT164204

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc5a8) plasma membrane (Slc5a8) transmembrane transport (Slc5a8)
Anatomy Link Frequency
colon 1
Slc5a8 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 77.92 Quite High
member 8 1 50.00 Quite Low
Bioavailability 3 48.48 Quite Low
Glutamate 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 1 88.96 High High
INFLAMMATION 3 77.68 Quite High
Apoptosis 15 36.48 Quite Low
Cancer 43 30.12 Quite Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Starvation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, ibuprofen functions as a blocker of SLC5A8 transport function.
Negative_regulation (blocker) of SLC5A8
1) Confidence 0.42 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.22 Pain Relevance 0.13
Slc5a8 levels were also reduced in colonic adenomatous polyps and hamartomas from Apc(+/Delta716) and Cdx2(+/-) mutant mice, respectively, compared with adjacent normal colon tissues.
Negative_regulation (reduced) of Slc5a8 in colon
2) Confidence 0.38 Published 2010 Journal Gastroenterology Section Body Doc Link 19900445 Disease Relevance 0 Pain Relevance 0

General Comments

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