INT164236

Context Info Confidence 0.50 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.27 Pain Relevance 0.09

transport (Cpt2) mitochondrion (Cpt2) nucleolus (Cpt2) nucleus (Cpt2) transferase activity, transferring acyl groups (Cpt2) lipid metabolic process (Cpt2)

Cpt2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 1 94.72 anesthesia 2 26.72 Bile 1 5.00 agonist 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 53 96.36 Rhabdomyolysis 1 95.48 Myalgia 1 94.72 Disorder Of Lipid Metabolism 45 85.12 Sudden Death 1 79.56 Fatty Liver 31 68.08 Stress 1 66.04 Hypoglycemia 2 65.16 Coronary Heart Disease 1 53.32 Body Weight 7 51.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To gain intensive insight into fatty acid metabolism, the following genes expressing the following proteins were measured: CPT1 and CPT2.

Gene_expression (expressing) of CPT2

1) Confidence 0.50 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.19 Pain Relevance 0

Late-onset CPTII probably cannot be detected.

Neg (cannot) Gene_expression (detected) of CPTII

2) Confidence 0.48 Published 2008 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 19904456 Disease Relevance 0.51 Pain Relevance 0.09

CPT-1and CPT-2 expression was inhibited by OA administration (P < 0.05), and both was stimulated with 0.05% dietary SSC treatment (P < 0.05).

Gene_expression (expression) of CPT-2 associated with hypersensitivity

3) Confidence 0.31 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.57 Pain Relevance 0

General Comments

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