INT164259

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 8
Total Number 32
Disease Relevance 27.50
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
animal tissue 2
lung 2
embryo 1
H19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 1 100.00 Very High Very High Very High
dexamethasone 1 97.84 Very High Very High Very High
imagery 12 97.52 Very High Very High Very High
abdominal pain 12 95.88 Very High Very High Very High
Adalimumab 1 90.06 High High
palliative 25 89.64 High High
Gabapentin 1 88.84 High High
Morphine 1 69.44 Quite High
anesthesia 25 65.40 Quite High
pregabalin 1 60.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 1815 100.00 Very High Very High Very High
Pancreatic Cancer 800 100.00 Very High Very High Very High
Pressure And Volume Under Development 168 99.42 Very High Very High Very High
Hypoxia 100 99.24 Very High Very High Very High
Death 56 99.04 Very High Very High Very High
Starvation 50 98.40 Very High Very High Very High
Diphtheria 142 98.04 Very High Very High Very High
Appetite Loss 12 96.68 Very High Very High Very High
Vomiting 36 96.28 Very High Very High Very High
Abdominal Pain 12 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three of the analyzed cell lines (CRL-2547, CRL-1687, and CRL-1469) showed high level of H19 expression (Figure 2(b), lanes 2 and 3 and Figure 2(a), lane 2, resp.), whereas the other two cell lines (CRL-2119 and CRL-1997) showed low levels of H19 expression (Figure 2(b), lanes 4 and 5, resp.).
Gene_expression (expression) of H19
1) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.68 Pain Relevance 0.06
High levels of H19 gene expression were detected in the developed tumors even though no expression was detected in cultured cells (Figure 5), which is in agreement with previous observations establishing that H19 gene expression may be induced by hypoxia and/or serum starvation conditions developed following injection of tumor cells into the animal tissue [17].
Gene_expression (expression) of H19 in animal tissue associated with starvation, hypoxia and cancer
2) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.24 Pain Relevance 0
High levels of H19 gene expression were detected in the developed tumors even though no expression was detected in cultured cells (Figure 5), which is in agreement with previous observations establishing that H19 gene expression may be induced by hypoxia and/or serum starvation conditions developed following injection of tumor cells into the animal tissue [17].
Gene_expression (expression) of H19 in animal tissue associated with starvation, hypoxia and cancer
3) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.19 Pain Relevance 0
Previous studies showed that H19 gene expression may be induced by hypoxia and/or serum starvation conditions and that the H19 gene may play a role in tumorogenesis [17, 20].
Gene_expression (expression) of H19 associated with starvation and hypoxia
4) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.62 Pain Relevance 0
We successfully demonstrated by ISH analysis that the H19 gene is expressed in 65% of the analyzed human pancreatic cancer samples (n = 49, Figure 1), indicating that treatment of human pancreatic cancer with the DTA-H19 is very likely to be effective in this disease.
Gene_expression (expressed) of H19 associated with pancreatic cancer and disease
5) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.33 Pain Relevance 0
H19 expression was also analyzed on PC.1-0 cells, a hamster pancreatic carcinoma cell line.
Spec (analyzed) Gene_expression (expression) of H19 associated with pancreatic cancer
6) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.74 Pain Relevance 0
The different cell lines used in this investigation were chosen because of their differences in the level of H19 gene expression and their response to transfection procedure.
Gene_expression (expression) of H19
7) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.26 Pain Relevance 0
Three of the analyzed cell lines (CRL-2547, CRL-1687, and CRL-1469) showed high level of H19 expression (Figure 2(b), lanes 2 and 3 and Figure 2(a), lane 2, resp.), whereas the other two cell lines (CRL-2119 and CRL-1997) showed low levels of H19 expression (Figure 2(b), lanes 4 and 5, resp.).
Gene_expression (expression) of H19
8) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.75 Pain Relevance 0
H19 gene was shown to be re-expressed in several cancer tissues derived from those tissues which expressed the gene during embryonic development [9], such as bladder cancer [10], hepatocellular carcinoma [11], adrenocortical tumors [12], choriocarcinoma [13], colorectal cancer [14], ovarian carcinoma, and lung carcinoma [15].
Gene_expression (-) of H19 in lung associated with lung cancer, cancer, colon cancer, hepatocellular cancer, bladder cancer and reprotox - general 1
9) Confidence 0.75 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.67 Pain Relevance 0
We constructed a plasmid in which the expression of DT-A is controlled by the transcriptional regulatory sequences of the H19 gene (DTA-H19).
Gene_expression (sequences) of H19 gene
10) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.73 Pain Relevance 0.03
Cells from our patient's ascites fluid were isolated for the detection of H19 RNA by in situ hybridization analyses (ISH) (Figure 1A) and by reverse transcriptase polymerase chain reaction (RT-PCR) analysis (Figure 1B).
Gene_expression (detection) of H19 RNA associated with pressure and volume under development
11) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 1.30 Pain Relevance 0.10
Therefore, the observed effect is more likely due to the cytotoxic effect of the DTA-H19 plasmid expression and not the result of competition between the two plasmids for the entry into the cell.
Gene_expression (expression) of H19
12) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.51 Pain Relevance 0
The activity of the H19 promoter was demonstrated in the human and hamster pancreatic tumor cells tested, leading to DTA expression (Figures 2 and 3).
Gene_expression (expression) of H19 associated with pancreatic cancer
13) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.26 Pain Relevance 0
g plasmid (DTA-H19 for treated group and Luc-H19 for control group) mixed with the nonviral transfectant polyethylenimine (Polyplus) (N/P = 6) diluted in 50??
Gene_expression (mixed) of H19
14) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.50 Pain Relevance 0.03
Since there is no report of the hamster's H19 gene sequence at the gene databases Ensembl and NCBI, primers designed originally for human and murine known H19 sequence were tested to determine H19 RNA level in hamster PC.1-0 cells.
Spec (determine) Gene_expression (level) of H19
15) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.67 Pain Relevance 0
H19 expression was previously determined in the developed tumors by RT-PCR analyses in order to validate the use of this animal model in evaluating the potential therapeutic effect of the toxin vector.
Spec (determined) Gene_expression (expression) of H19 associated with cancer
16) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.08 Pain Relevance 0
This approach consists of a DNA-based therapy expressing a toxin under the control of regulatory sequences of a differentially expressed gene, the H19 gene.
Gene_expression (expressed) of H19
17) Confidence 0.65 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.23 Pain Relevance 0
Data regarding the correlation between the level of H19 expression and the efficacy of the treatment should be collected during a Phase I and II clinical trials which are being planned.
Gene_expression (expression) of H19
18) Confidence 0.60 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.72 Pain Relevance 0
We constructed a plasmid in which the expression of DT-A is controlled by the transcriptional regulatory sequences of the H19 gene (DTA-H19).
Gene_expression (sequences) of DTA-H19
19) Confidence 0.58 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.73 Pain Relevance 0.03
The rapid reduction of cells in the ascites fluid might indicate that DTA was expressed from the DTA-H19 vector and caused cell death.
Gene_expression (expressed) of DTA-H19 associated with pressure and volume under development and death
20) Confidence 0.58 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 1.16 Pain Relevance 0.05

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