INT164302

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nox4) oxidoreductase activity (Nox4) aging (Nox4)
cell morphogenesis (Nox4) endoplasmic reticulum (Nox4) plasma membrane (Nox4)
Anatomy Link Frequency
podocytes 2
Nox4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 2 68.00 Quite High
member 8 1 63.72 Quite High
antagonist 2 15.84 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 3 96.32 Very High Very High Very High
Nephrosis 2 93.16 High High
Focal Segmental Glomerulosclerosis 3 86.88 High High
Injury 6 80.48 Quite High
Hypertension 14 78.08 Quite High
Fibrosis 3 68.00 Quite High
Renal Disease 1 67.32 Quite High
Necrosis 1 65.28 Quite High
Hyperplasia 1 65.12 Quite High
Cancer 1 64.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vitro study, PAN significantly increased NOX4 and TRPC6 expression levels in cultured podocytes.
Positive_regulation (increased) of Gene_expression (expression) of NOX4 in podocytes
1) Confidence 0.42 Published 2009 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 19910702 Disease Relevance 0.79 Pain Relevance 0.06
Similarly, aldosterone infusion showed elevated renal tissue ROS levels which were associated with increased mRNA expression of p22phox, Nox-4, and gp91phox (10).
Positive_regulation (increased) of Gene_expression (expression) of Nox-4
2) Confidence 0.17 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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