INT164322

Context Info Confidence 0.50 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.57 Pain Relevance 1.13

transport (Abcg2) ATPase activity (Abcg2) plasma membrane (Abcg2) nucleus (Abcg2)

Anatomy Link Frequency MCF-7 2 B-cell 1 Abcg2 (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 20 99.70 cINOD 4 97.84 Calcium channel 2 5.00 cytokine 1 5.00 anesthesia 1 5.00 Nerve growth factor 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 16 99.84 INFLAMMATION 4 97.64 Lymphatic System Cancer 2 97.60 Aging 1 90.76 Obesity 1 5.00 Apoptosis 1 5.00 Adhesions 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SP cells expressed higher levels of the stem cell markers ATP-binding cassette transporter G2 (ABCG2), p75 neurotrophin receptor (p75NTR), nestin (nes), B-cell lymphoma 2 (Bcl2), and cell surface antigen Sca-1 mRNA than the main population cells.

Transcription (expressed) of ABCG2 in B-cell associated with lymphatic system cancer

1) Confidence 0.50 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2890558 Disease Relevance 0.19 Pain Relevance 0

Dexamethasone downregulates BCRP mRNA and protein expression in breast cancer cell lines.

Transcription (expression) of BCRP associated with breast cancer and dexamethasone

2) Confidence 0.26 Published 2009 Journal Oncol. Res. Section Title Doc Link 19911699 Disease Relevance 0.37 Pain Relevance 0.30

For evaluation of BCRP mRNA expression, relative quantitative PCR and comparative C1 method was exploited.

Transcription (expression) of BCRP

3) Confidence 0.26 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.25

Dexamethasone showed a dose-independent and a time-dependent effect on decreasing the mRNA level of BCRP gene in comparison with control in MCF-7 and MCF-7/MX breast cancer cell lines, whereas no changes were noted in the presence of indomethacin.

Transcription (level) of BCRP in MCF-7 associated with breast cancer and dexamethasone

4) Confidence 0.19 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.29

Dexamethasone showed a dose-independent and a time-dependent effect on decreasing the mRNA level of BCRP gene in comparison with control in MCF-7 and MCF-7/MX breast cancer cell lines, whereas no changes were noted in the presence of indomethacin.

Transcription (level) of BCRP in MCF-7 associated with breast cancer and dexamethasone

5) Confidence 0.06 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19911699 Disease Relevance 0.34 Pain Relevance 0.29

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