INT164433

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.71 Pain Relevance 0.29

extracellular space (Il12a, Il6) extracellular region (Il12a, Il6) cytoplasm (Il12a)

Anatomy Link Frequency plasma 1 Il12a (Mus musculus) Il6 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 3 100.00 Catecholamine 1 100.00 Inflammation 1 74.52 headache 2 60.04

Disease Link Frequency Relevance Heat Epidermal Cyst 1 100.00 Infection 3 99.54 Cold Sores 3 99.30 Meningitis 7 95.20 Cerebral Toxoplasmosis 5 92.00 Increased Venous Pressure Under Development 1 89.00 INFLAMMATION 1 74.52 Toxoplasmosis 1 74.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 60.48 Headache 2 60.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Examples of triggers revealing MM and accompanying disturbances of IFN-gamma-mediated immune responses that control HSV-2 and T. gondii include: female predominance (female mice are more susceptible to T. gondii infection than males); HSV-2 infection (increased IFN-gamma, IL-12); metaraminol (increased plasma catecholamine levels, changes in cytokine expression favoring T(H)2 cells responses); probably cholesterol contained in debris from ruptured epidermoid cysts (decreased NO; increased TNF-alpha, IL-6, IL-8).

IL-12 Positive_regulation (increased) of IL-6 in plasma associated with epidermal cyst, cold sores, meningitis, catecholamine, infection and cytokine

1) Confidence 0.01 Published 2009 Journal Int. J. Neurosci. Section Abstract Doc Link 19922380 Disease Relevance 1.71 Pain Relevance 0.29

General Comments

This test has worked.