INT164480

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 10.84
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
eyes 6
microglia 3
ventricles 2
retina 2
optic 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 66 99.96 Very High Very High Very High
Spinal cord 105 99.60 Very High Very High Very High
Neuritis 79 98.88 Very High Very High Very High
ischemia 82 98.82 Very High Very High Very High
Central nervous system 201 91.80 High High
Multiple sclerosis 74 90.20 High High
medulla 9 89.20 High High
cerebral cortex 4 87.12 High High
Demyelination 58 79.48 Quite High
Peripheral nervous system 1 73.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 66 99.96 Very High Very High Very High
Middle Cerebral Artery Infarction 213 99.82 Very High Very High Very High
Hypoxia 9 99.64 Very High Very High Very High
Injury 130 99.30 Very High Very High Very High
Demyelinating Disease 106 99.08 Very High Very High Very High
Optic Neuritis 76 98.88 Very High Very High Very High
Cv Unclassified Under Development 31 98.82 Very High Very High Very High
Neuromyelitis Optica 692 98.72 Very High Very High Very High
Ocular Hypertension 226 98.12 Very High Very High Very High
Stroke 18 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in AQP4 expression five days post-hatching in normal eyes is not surprising if, as we have postulated, AQP4 expression on the vitreal border is an indication of resultant fluid dispersion in ocular growth.
Negative_regulation (decrease) of Gene_expression (expression) of AQP4 in eyes
1) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.13 Pain Relevance 0
In particular the MCAO-induced overexpression of cerebral AQP4 can be greatly reduced by agmatine therapy, suggesting that the enhanced water movement associated with the pathophysiology of cerebral edema after transient cerebral ischemia is attenuated by agmatine.
Negative_regulation (reduced) of Gene_expression (overexpression) of AQP4 associated with transient ischemic attack, pressure and volume under development, middle cerebral artery infarction and ischemia
2) Confidence 0.55 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.82 Pain Relevance 0.09
Moreover agmatine treatment decreased the AQP4 expression in ischemic mice [22].
Negative_regulation (decreased) of Gene_expression (expression) of AQP4
3) Confidence 0.55 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.18 Pain Relevance 0.11
-dystroglycan did not reduce AQP4 expression in all end-feet membranes, as AQP4 labeling was retained in the end-feet that impinge on the subarachnoidal space and in cells that line the ventricles.
Neg (not) Negative_regulation (reduce) of Gene_expression (expression) of AQP4 in ventricles
4) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.07 Pain Relevance 0.05
Even in patches of so-called normal appearing white matter where there is no other evidence of inflammation, AQP4 expression has been shown to be reduced.
Negative_regulation (reduced) of Gene_expression (expression) of AQP4 in white matter associated with inflammation
5) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.39 Pain Relevance 0.46
AQP4 expression was significantly decreased (Kruskal-Wallis) relative to control in both the periventricular region after two days of hydrocephalus (control: 1.00, 0.95-1.04, two day: 0.78, 0.63-0.084, p < 0.05) and in the cortex (control: 1.00, 0.93-1.14, two day: 0.81, 0.67-0.97, p < 0.05) and normalized after one week.
Negative_regulation (decreased) of Gene_expression (expression) of AQP4 in cortex associated with hydrocephalus
6) Confidence 0.43 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.10 Pain Relevance 0
Fluorescence staining for AQP4 and GFAP or lectin revealed that astroglia are the main source of AQP4 expression in the brain, while endothelial cells and microglia are devoid of AQP4 expression (Figure 7 and Figure 8).
Negative_regulation (source) of Gene_expression (expression) of AQP4 in microglia
7) Confidence 0.43 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.06 Pain Relevance 0
We pathologically diagnosed this case as NMO for optic neuritis, myelitis, a contiguous spinal cord lesion and loss or decrease of AQP4 expression.
Negative_regulation (decrease) of Gene_expression (expression) of AQP4 in optic associated with neuromyelitis optica, optic neuritis, demyelinating disease, neuritis and spinal cord
8) Confidence 0.42 Published 2010 Journal Neuropathology Section Abstract Doc Link 19925565 Disease Relevance 0.62 Pain Relevance 0.42
As shown in Figure 3A, nine out of 11 rats (82%, Figure 3A) showed a decrease in AQP4 protein levels in ET-1 injected eyes (70±10%, p<0.05) and AQP4 protein levels decreased in five out seven rats following elevation of IOP (71%; 72±12% p<0.001, 3C).
Negative_regulation (decrease) of Gene_expression (levels) of AQP4 protein in eyes associated with ocular hypertension
9) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.99 Pain Relevance 0
In addition, AQP4 deletion in mice is neuroprotective in a transient ischemia model of retinal injury [37] and hypoxia induced a marked decrease in AQP4 mRNA levels in astrocytes in vitro [38], suggesting that the reduction of AQP4 levels may be a beneficial mechanism.
Negative_regulation (decrease) of Gene_expression (levels) of AQP4 mRNA in astrocytes associated with hypoxia, ischemia and injury
10) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.36 Pain Relevance 0.16
As shown in Figure 3A, nine out of 11 rats (82%, Figure 3A) showed a decrease in AQP4 protein levels in ET-1 injected eyes (70±10%, p<0.05) and AQP4 protein levels decreased in five out seven rats following elevation of IOP (71%; 72±12% p<0.001, 3C).
Negative_regulation (decreased) of Gene_expression (levels) of AQP4 protein in eyes associated with ocular hypertension
11) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.99 Pain Relevance 0
The pattern of distribution of AQP4 expression across the retina was similar in all groups examined.
Negative_regulation (distribution) of Gene_expression (expression) of AQP4 in retina
12) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.17 Pain Relevance 0
A more recent report showed agmatine treatment decreased the AQP4 expression in ischemic mice [22].
Negative_regulation (decreased) of Gene_expression (expression) of AQP4
13) Confidence 0.40 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2941483 Disease Relevance 1.27 Pain Relevance 0.16
-syntrophin results in loss of AQP4 expression in astrocyte end-feet but not in AQP4 expressing cells in the kidney or osmosensitive regions of the brain [26]. ?
Negative_regulation (loss) of Gene_expression (expression) of AQP4 in kidney
14) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0 Pain Relevance 0.04
Currently, immunocytochemical detection of AQP-4 loss in the lesions is regarded as a very good diagnostic marker for NMO lesions.
Negative_regulation (detection) of Gene_expression (loss) of AQP-4 associated with neuromyelitis optica
15) Confidence 0.34 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.63 Pain Relevance 0.04
Fluorescence staining for AQP4 and GFAP or lectin revealed that astroglia are the main source of AQP4 expression in the brain, while endothelial cells and microglia are devoid of AQP4 expression (Figure 7 and Figure 8).
Negative_regulation (source) of in endothelial cells Gene_expression (expression) of AQP4 in microglia
16) Confidence 0.15 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.06 Pain Relevance 0

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