INT164517

Context Info Confidence 0.13 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.22

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2) nucleolus (CABIN1) nucleus (CABIN1) cell-cell signaling (IL2)

CABIN1 (Homo sapiens) IL2 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 2 91.68 Kinase C inhibitor 1 85.36 psoriasis 1 65.04 headache 1 53.76

Disease Link Frequency Relevance Heat Organ Transplantation 2 91.32 Psoriasis 1 65.04 Gastrointestinal Disease 1 56.24 Headache 1 53.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This complex of ciclosporin and cyclophilin inhibits calcineurin, which is responsible for activating the transcription of interleukin-2.

calcineurin Positive_regulation (responsible) of Transcription (transcription) of interleukin-2

1) Confidence 0.13 Published 2009 Journal Clin Transplant Section Abstract Doc Link 19930311 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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