INT164585

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PMAIP1) mitochondrion (PMAIP1) nucleus (PMAIP1)
PMAIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 98.08 Very High Very High Very High
cINOD 1 54.96 Quite High
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 12 100.00 Very High Very High Very High
Leukemia 4 98.68 Very High Very High Very High
Chronic Lymphoid Leukemia 1 97.40 Very High Very High Very High
Apoptosis 21 96.04 Very High Very High Very High
Mantle-cell Lymphoma 1 93.10 High High
Skin Cancer 1 92.60 High High
Stress 1 60.08 Quite High
Hypoxia 1 55.32 Quite High
INFLAMMATION 2 54.72 Quite High
Death 1 40.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This alteration of the Mcl-1/Noxa balance was also found in other leukemia cell lines and primary chronic lymphocytic leukemia cells (CLL).
Regulation (alteration) of Noxa associated with chronic lymphoid leukemia and leukemia
1) Confidence 0.20 Published 2010 Journal Apoptosis Section Abstract Doc Link 19936928 Disease Relevance 1.06 Pain Relevance 0.61
Bortezomib induction of NOXA is also seen in melanoma and mantle cell lymphoma cell lines, with antisense NOXA oligonucleotide (but not control) resulting in a decrease in bortezomib induced apoptosis.71,74 Of note, apoptosis/NOXA induction is not induced by conventional chemotherapeutic agents but is induced by other proteasome inhibitors (eg, MG132), suggesting a possible class specific effect.73,75 To understand why NOXA is preferentially induced in tumor cells, the myriad transcription factors with consensus binding sites at the NOXA promoter were restricted to those that are conserved (as NOXA itself is) across mammalian species and also dysregulated by proteasome inhibition and tumorogenesis.
Regulation (dysregulated) of NOXA associated with mantle-cell lymphoma, cancer, apoptosis and skin cancer
2) Confidence 0.16 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 1.00 Pain Relevance 0

General Comments

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