INT164782

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.67

extracellular space (Il6) aging (Il6) extracellular region (Il6) plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)

Anatomy Link Frequency sciatic nerve 2 Il6 (Rattus norvegicus) Cx3cr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 5 98.72 Eae 6 97.56 Sciatic nerve 1 95.92 Neuropathic pain 3 92.24 Peripheral nerve injury 3 91.12 Pain 2 76.56 allodynia 1 32.80 Thermal hyperalgesia 1 31.68

Disease Link Frequency Relevance Heat Injury 6 96.72 Neuropathic Pain 4 92.24 Nervous System Injury 4 91.12 Pain 2 76.56 Hyperalgesia 1 31.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we investigated whether IL-6 regulates CX3CR1 expression through p38 MAPK activation in the spinal cord in rats with chronic constriction injury (CCI) of the sciatic nerve.

IL-6 Spec (whether) Regulation (regulates) of Gene_expression (expression) of CX3CR1 in sciatic nerve associated with eae, injury, sciatic nerve and spinal cord

1) Confidence 0.27 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959384 Disease Relevance 0.79 Pain Relevance 0.67

General Comments

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