INT165084

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.40
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
muscle 1
brain 1
DRG 1
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 77 99.78 Very High Very High Very High
Root ganglion neuron 2 99.04 Very High Very High Very High
bradykinin 2 98.78 Very High Very High Very High
Pain 27 98.60 Very High Very High Very High
Serotonin 3 98.10 Very High Very High Very High
Nerve growth factor 34 97.86 Very High Very High Very High
Inflammatory mediators 2 97.18 Very High Very High Very High
ASIC 22 96.84 Very High Very High Very High
vanilloid receptor subtype 1 1 91.48 High High
c fibre 17 91.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 99.78 Very High Very High Very High
Ganglion Cysts 68 98.84 Very High Very High Very High
Pain 29 98.60 Very High Very High Very High
Acidosis 17 97.68 Very High Very High Very High
Inflammatory Pain 36 89.60 High High
Hematoma 1 85.52 High High
Cv Unclassified Under Development 2 85.08 High High
Infection 4 84.68 Quite High
Nociception 10 81.48 Quite High
Targeted Disruption 15 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, inflammatory mediators, such as nerve growth factor (NGF), serotonin (5-HT), interleukin-1, bradykinin, and brain-derived neurotrophic factor (BDNF) can stimulate ASIC3 transcription, which perhaps contributes to the pain-enhancing effects of these mediators [49,50].
Transcription (transcription) of ASIC3 in brain associated with pain, inflammatory mediators, nerve growth factor, bradykinin and serotonin
1) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.02 Pain Relevance 0.91
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Transcription (expression) of ASIC3 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
2) Confidence 0.51 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.01 Pain Relevance 0.45
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Transcription (expression) of ASIC3 in DRG associated with inflammation
3) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 1.05
Analysis of the expression of putative mechanosensitive ion channels by RT-PCR shows increased mRNA levels for acid-sensitive ion channel 2a (ASIC2a) and ASIC2b but not for ASIC1 and ASIC3 in GDNF-overexpressing animals.
Transcription (levels) of ASIC3
4) Confidence 0.24 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.60

General Comments

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