INT16527

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.01
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
plasma 2
pituitary 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 5 99.60 Very High Very High Very High
Somatostatin 5 94.92 High High
agonist 7 93.64 High High
Sumatriptan 10 91.68 High High
opiate 1 86.80 High High
antagonist 1 86.24 High High
narcan 3 84.56 Quite High
Opioid 4 76.16 Quite High
Neurotransmitter 3 75.00 Quite High
Serotonin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 8 99.64 Very High Very High Very High
Eating Disorder 1 99.36 Very High Very High Very High
Weight Loss 1 75.00 Quite High
Headache 3 71.92 Quite High
Bronchopulmonary Dysplasia 5 63.84 Quite High
Body Weight 3 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that (a) pituitary responsiveness to GHRH changes throughout the estrous cycle is maximal in diestrus and minimal in proestrus; (b) GHRH stimulated GH secretion in intact and ovariectomized females on days 45, 60 and 90, but not on day 30; (c) the age increase of GH responsiveness to GHRH administration was slightly reduced in animals ovariectomized on day 23; (e) the age increase of pituitary GH content was similar in control and ovariectomized females; and (d) ovariectomy on day 83 reduced pituitary responsiveness to GHRH more effectively than ovariectomy on day 23.
Negative_regulation (reduced) of Positive_regulation (responsiveness) of GHRH in pituitary
1) Confidence 0.43 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1834957 Disease Relevance 0 Pain Relevance 0.06
These results indicate that HST calves responded to exogenous GHRF with an abrupt increase in plasma GH, but GH response to GHRF during SRIH infusion was greatly inhibited.
Negative_regulation (inhibited) of Positive_regulation (response) of GHRF in plasma
2) Confidence 0.42 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2904152 Disease Relevance 0 Pain Relevance 0.08
Previously, we have shown that in the opposite extremes of nutritional status (obesity and anorexia nervosa [AN]), the growth hormone (GH) response to GH-releasing hormone (GHRH) is not inhibited by the ingestion of a normal 800-kcal meal at noon.
Negative_regulation (inhibited) of Positive_regulation (response) of GHRH associated with obesity and eating disorder
3) Confidence 0.21 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11288030 Disease Relevance 0.69 Pain Relevance 0.36
In the obese subjects, the GH response to GHRH was reduced (7.3 +/- 1.0 vs. 29.6 +/- 9.7 micrograms/L at 30 min) compared to that in control children (P < 0.05).
Negative_regulation (reduced) of Positive_regulation (response) of GHRH associated with obesity
4) Confidence 0.14 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.18 Pain Relevance 0.95
Clonidine and BRO (10(-6) M) inhibited basal and GHRH (10(-10) M)-stimulated GH release.
Negative_regulation (inhibited) of Positive_regulation (-stimulated) of GHRH associated with clonidine
5) Confidence 0.12 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.78
GH response to GHRH was significantly reduced in patients with CM-MOH in comparison with controls.
Negative_regulation (reduced) of Positive_regulation (response) of GHRH
6) Confidence 0.11 Published 2006 Journal Headache Section Body Doc Link 16643554 Disease Relevance 0.14 Pain Relevance 0

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