INT165347

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPE) protein modification process (CPE) extracellular region (CPE)
Golgi apparatus (CPE) plasma membrane (CPE) nucleus (CPE)
Anatomy Link Frequency
alveolar macrophages 1
glands 1
CPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 8 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Kappa opioid receptor 3 99.32 Very High Very High Very High
opioid receptor 3 98.60 Very High Very High Very High
substance P 2 81.84 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 5 93.80 High High
Cancer 2 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization of proenkephalin with met-enkephalin, prohormone convertase 1, prohormone convertase 2, and carboxypeptidase E was demonstrated by double-immunofluorescence confocal microscopy in alveolar macrophages, submucosal glands, cancerous cells, and pulmonary neuroendocrine cells of bronchial epithelium.
Localization (Colocalization) of carboxypeptidase E in glands associated with enkephalin
1) Confidence 0.55 Published 2010 Journal Hum. Pathol. Section Abstract Doc Link 20040394 Disease Relevance 0.16 Pain Relevance 0.84
Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients.
Localization (colocalization) of carboxypeptidase E in alveolar macrophages associated with dynorphin, kappa opioid receptor and opioid
2) Confidence 0.43 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20376782 Disease Relevance 0.42 Pain Relevance 0.71

General Comments

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