INT165637

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ptpn6, Nfkb1) nucleus (Ptpn6, Nfkb1) cell differentiation (Ptpn6)
phosphatase activity (Ptpn6) mitochondrion (Nfkb1) DNA binding (Nfkb1)
Ptpn6 (Mus musculus)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 98.52 Very High Very High Very High
Inflammation 2 75.00 Quite High
Antinociceptive 2 75.00 Quite High
COX2 1 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 98.52 Very High Very High Very High
Nociception 1 98.20 Very High Very High Very High
Necrosis 1 80.24 Quite High
Cancer 1 79.88 Quite High
Encephalitis 1 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, above results indicate that ME10092 inhibits NF-kappaB activation and suppresses the up-regulation of inflammatory mediators in experimental models in vivo.
ME10092 Negative_regulation (inhibits) of Positive_regulation (activation) of NF-kappaB associated with inflammatory mediators
1) Confidence 0.02 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.57 Pain Relevance 0.23

General Comments

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