INT165645

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
myocytes 2
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Brush evoked pain 6 97.44 Very High Very High Very High
Spinal cord 4 90.80 High High
dorsal root ganglion 1 74.76 Quite High
antiallodynic 1 67.48 Quite High
antagonist 1 60.32 Quite High
headache 6 48.08 Quite Low
nud 5 47.04 Quite Low
backache 6 42.64 Quite Low
Analgesic 1 25.00 Low Low
withdrawal 1 9.84 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 24 97.92 Very High Very High Very High
Neuropathic Pain 6 97.44 Very High Very High Very High
Erectile Dysfunction 69 89.88 High High
Polyuria 1 83.52 Quite High
Disease 16 77.48 Quite High
Ganglion Cysts 1 74.76 Quite High
Hypertension 13 74.36 Quite High
Headache 6 48.08 Quite Low
Dyspepsia 5 47.04 Quite Low
Back Pain 6 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these patients, either psychogenic erections or reflexive spinally elicited erections or both are necessary for PDE5 inhibitor response.
Positive_regulation (necessary) of Negative_regulation (inhibitor) of PDE5
1) Confidence 0.37 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699638 Disease Relevance 0.22 Pain Relevance 0.05
Moreover, both drugs reversed streptozotocin-induced phosphodiesterase 5A2 mRNA expression reduction.
Positive_regulation (induced) of Negative_regulation (reduction) of phosphodiesterase 5A2
2) Confidence 0.33 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.21 Pain Relevance 0.66
PDE4 is not inhibited by cGMP and thus originally PDE3 was called cGMP-inhibited PDE to distinguish it from PDE4. cGMP inhibition of PDE3 may be physiologically relevant to the elevation of cAMP levels in a variety of cells including human myocytes, where nitric oxide induced relaxation may be mediated by activation of guanylyl cyclase, elevation of intracellular cGMP levels and inhibition of PDE3 leading to elevated cAMP levels (Kirstein et al 1995).
Positive_regulation (relevant) of Negative_regulation (inhibition) of cGMP in myocytes
3) Confidence 0.13 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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