INT165648

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 3.60
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
spinal cord 2
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.84 Very High Very High Very High
Brush evoked pain 18 99.64 Very High Very High Very High
dorsal root ganglion 3 88.96 High High
antiallodynic 3 81.68 Quite High
Analgesic 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 18 99.64 Very High Very High Very High
Diabetes Mellitus 24 99.24 Very High Very High Very High
Polyuria 3 98.86 Very High Very High Very High
Ganglion Cysts 3 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Streptozotocin injection produced hyperlglycemia, polydipsia, polyphagia and polyuria as well as long-term tactile allodynia (12 weeks) and a reduction of phosphodiesterase 5A2 mRNA expression in spinal cord of diabetic rats.
Negative_regulation (reduction) of Transcription (expression) of phosphodiesterase 5A2 in spinal cord associated with brush evoked pain, polyuria, diabetes mellitus and spinal cord
1) Confidence 0.41 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.17 Pain Relevance 0.59
Moreover, both drugs reversed streptozotocin-induced phosphodiesterase 5A2 mRNA expression reduction.
Negative_regulation (reversed) of Transcription (expression) of phosphodiesterase 5A2
2) Confidence 0.31 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.22 Pain Relevance 0.67
Moreover, both drugs reversed streptozotocin-induced phosphodiesterase 5A2 mRNA expression reduction.
Negative_regulation (reduction) of Transcription (expression) of phosphodiesterase 5A2
3) Confidence 0.31 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20079349 Disease Relevance 1.21 Pain Relevance 0.66

General Comments

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